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    Repair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1.

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    Authors
    Chu, Yung-Hua
    Craig, Alister W
    O'Connor, Peter J
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Instute, Manchester M20 9BX
    Issue Date
    1981-06
    
    Metadata
    Show full item record
    Abstract
    Pretreatment of rats by the repeated administration of certain alkylating carcinogens has been shown to stimulate the removal of O6-alkylguanine from hepatic DNA. Prolonged feeding with the aromatic amide 2-acetylaminofluorene has a similar effect. In this report, aflatoxin B1, an agent from another chemically distinct class of carcinogen, is shown to be capable of stimulating the repair of O6-methylguanine in hepatic DNA. The sensitivity of this system is shown by the fact that this repair response can be fully stimulated as early as 1 day after treatment with a single dose.
    Citation
    Repair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1. 1981, 43 (6):850-5 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/135868
    PubMed ID
    6788062
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

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