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dc.contributor.authorLee, C E
dc.contributor.authorPrabhu, V
dc.contributor.authorSlevin, Nicholas J
dc.date.accessioned2011-07-12T16:33:07Z
dc.date.available2011-07-12T16:33:07Z
dc.date.issued2011-03
dc.identifier.citationCollagen vascular diseases and enhanced radiotherapy-induced normal tissue effects--a case report and a review of published studies. 2011, 23 (2):73-8 Clin Oncolen
dc.identifier.issn1433-2981
dc.identifier.pmid21168314
dc.identifier.doi10.1016/j.clon.2010.08.030
dc.identifier.urihttp://hdl.handle.net/10541/135865
dc.description.abstractCollagen vascular diseases (CVD) are a group of chronic, autoimmune conditions that can affect multiple organ systems. The mainstay of treatment involves the use of immunosuppressants. CVDs and immunosuppression increase the risk of these patients developing malignancy. The mechanisms through which these patients develop CVDs show similarities to those for radiotherapy late effects, especially fibrosis (via transforming growth factor β). Radiotherapy may in fact cause an active state to develop from a quiescent state of CVD, or exacerbate a pre-existing CVD. CVDs are said to be associated with increased normal tissue toxicity after radiotherapy. Here we present a case report of a patient with a long history of systemic lupus erythematosus and oropharyngeal carcinoma, treated with synchronous chemoradiotherapy. We also review published studies and formulate some guidance on the radiotherapy management of these patients.
dc.language.isoenen
dc.subject.meshCarcinoma
dc.subject.meshCollagen Diseases
dc.subject.meshCombined Modality Therapy
dc.subject.meshHumans
dc.subject.meshLupus Erythematosus, Systemic
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOropharyngeal Neoplasms
dc.subject.meshPractice Guidelines as Topic
dc.subject.meshRadiation Injuries
dc.subject.meshRadiotherapy
dc.subject.meshVascular Diseases
dc.titleCollagen vascular diseases and enhanced radiotherapy-induced normal tissue effects--a case report and a review of published studies.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Christie Hospital, Manchester, UK. carolinelee@christie.nhs.co.uken
dc.identifier.journalClinical Oncologyen
html.description.abstractCollagen vascular diseases (CVD) are a group of chronic, autoimmune conditions that can affect multiple organ systems. The mainstay of treatment involves the use of immunosuppressants. CVDs and immunosuppression increase the risk of these patients developing malignancy. The mechanisms through which these patients develop CVDs show similarities to those for radiotherapy late effects, especially fibrosis (via transforming growth factor β). Radiotherapy may in fact cause an active state to develop from a quiescent state of CVD, or exacerbate a pre-existing CVD. CVDs are said to be associated with increased normal tissue toxicity after radiotherapy. Here we present a case report of a patient with a long history of systemic lupus erythematosus and oropharyngeal carcinoma, treated with synchronous chemoradiotherapy. We also review published studies and formulate some guidance on the radiotherapy management of these patients.


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