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    Collagen vascular diseases and enhanced radiotherapy-induced normal tissue effects--a case report and a review of published studies.

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    Authors
    Lee, C E
    Prabhu, V
    Slevin, Nicholas J
    Affiliation
    Department of Clinical Oncology, Christie Hospital, Manchester, UK. carolinelee@christie.nhs.co.uk
    Issue Date
    2011-03
    
    Metadata
    Show full item record
    Abstract
    Collagen vascular diseases (CVD) are a group of chronic, autoimmune conditions that can affect multiple organ systems. The mainstay of treatment involves the use of immunosuppressants. CVDs and immunosuppression increase the risk of these patients developing malignancy. The mechanisms through which these patients develop CVDs show similarities to those for radiotherapy late effects, especially fibrosis (via transforming growth factor β). Radiotherapy may in fact cause an active state to develop from a quiescent state of CVD, or exacerbate a pre-existing CVD. CVDs are said to be associated with increased normal tissue toxicity after radiotherapy. Here we present a case report of a patient with a long history of systemic lupus erythematosus and oropharyngeal carcinoma, treated with synchronous chemoradiotherapy. We also review published studies and formulate some guidance on the radiotherapy management of these patients.
    Citation
    Collagen vascular diseases and enhanced radiotherapy-induced normal tissue effects--a case report and a review of published studies. 2011, 23 (2):73-8 Clin Oncol
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/135865
    DOI
    10.1016/j.clon.2010.08.030
    PubMed ID
    21168314
    Type
    Article
    Language
    en
    ISSN
    1433-2981
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2010.08.030
    Scopus Count
    Collections
    All Christie Publications
    Clinical Oncology

    entitlement

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