• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    The dose-dependence of the split-dose response of marrow colony-forming units (CFU-S): similarity to other tissues.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Hendry, Jolyon H
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1979-12
    
    Metadata
    Show full item record
    Abstract
    The split-dose effect for survival of colony-forming units (CFU-S) in mouse bone-marrow increases with increasing total dose. This is compatible with the shape of the survival curve, since detailed measurements at doses lower than 200 rad show the presence of a marked initial slope, followed by a tendency towards an increased sensitivity at higher doses. The magnitude of the increase in the split-dose effect is quantitatively similar to values observed by others at comparable low doses in skin, intestine and lung, as deduced from multifraction experiments. It is concluded that these cells do not differ markedly, as has been generally believed, from many other cell types in the ability to demonstrate split-dose effects, when the doses used in the experiments are strictly comparable.
    Citation
    The dose-dependence of the split-dose response of marrow colony-forming units (CFU-S): similarity to other tissues. 1979, 36 (6):631-7 Int J Radiat Biol Relat Stud Phys Chem Med
    Journal
    International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
    URI
    http://hdl.handle.net/10541/135859
    DOI
    10.1080/09553007914551461
    PubMed ID
    317954
    Type
    Article
    Language
    en
    ISSN
    0020-7616
    ae974a485f413a2113503eed53cd6c53
    10.1080/09553007914551461
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Effects of low level radiation upon the hematopoietic stem cell: implications for leukemogenesis.
    • Authors: Cronkite EP, Bond VP, Carsten AL, Inoue T, Miller ME, Bullis JE
    • Issue date: 1987
    • CFU-S repopulation after low-dose whole-body radiation.
    • Authors: Schofield R, Dexter TM
    • Issue date: 1982 Mar
    • Gamma-ray-induced cell killing and chromosome abnormalities in the bone marrow of p53-deficient mice.
    • Authors: Wang L, Cui Y, Lord BI, Roberts SA, Potten CS, Hendry JH, Scott D
    • Issue date: 1996 Sep
    • Radiosensitivity and recovery of two murine haemopoietic progenitor cell populations following gamma rays and neutrons.
    • Authors: Millard RE, Blackett NM
    • Issue date: 1981
    • Effect of short-term splitting of gamma-ray doses on changes in haemopoietic stem cell number in bone marrow and on mortality of whole-body irradiated mice.
    • Authors: Vávrová J, Petýrek P
    • Issue date: 1988
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.