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dc.contributor.authorIype, P
dc.contributor.authorAllen, Terence D
dc.date.accessioned2011-07-11T08:35:41Z
dc.date.available2011-07-11T08:35:41Z
dc.date.issued1979-01
dc.identifier.citationIdentification of transformed rat liver epithelial cells in culture. 1979, 6 (1):27-32 Cancer Letten
dc.identifier.issn0304-3835
dc.identifier.pmid544009
dc.identifier.doi10.1016/S0304-3835(79)80016-6
dc.identifier.urihttp://hdl.handle.net/10541/135772
dc.description.abstractThe growth potential of normal and transformed rat liver epithelial cells in culture was investigated under various experimental conditions. The control cells failed to form colonies over a base layer of living parent cells, whereas transformed cells formed distinct colonies. Contact with living normal liver cells is required for the growth inhibition of the untransformed cells. Malignant cells capable of producing hepatocellular carcinomas in vivo exhibited signs of invasion in vitro. Altered properties of hepatic cells during the early stages of transformation can be assessed by plating such cell population over a living base layer of normal liver cells.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Line
dc.subject.meshCell Transformation, Neoplastic
dc.subject.meshCells, Cultured
dc.subject.meshEpithelial Cells
dc.subject.meshLiver
dc.subject.meshLiver Neoplasms, Experimental
dc.subject.meshMicroscopy, Electron
dc.subject.meshRats
dc.titleIdentification of transformed rat liver epithelial cells in culture.en
dc.typeArticleen
dc.identifier.journalCancer Lettersen
html.description.abstractThe growth potential of normal and transformed rat liver epithelial cells in culture was investigated under various experimental conditions. The control cells failed to form colonies over a base layer of living parent cells, whereas transformed cells formed distinct colonies. Contact with living normal liver cells is required for the growth inhibition of the untransformed cells. Malignant cells capable of producing hepatocellular carcinomas in vivo exhibited signs of invasion in vitro. Altered properties of hepatic cells during the early stages of transformation can be assessed by plating such cell population over a living base layer of normal liver cells.


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