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    Identification of transformed rat liver epithelial cells in culture.

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    Authors
    Iype, P
    Allen, Terence D
    Issue Date
    1979-01
    
    Metadata
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    Abstract
    The growth potential of normal and transformed rat liver epithelial cells in culture was investigated under various experimental conditions. The control cells failed to form colonies over a base layer of living parent cells, whereas transformed cells formed distinct colonies. Contact with living normal liver cells is required for the growth inhibition of the untransformed cells. Malignant cells capable of producing hepatocellular carcinomas in vivo exhibited signs of invasion in vitro. Altered properties of hepatic cells during the early stages of transformation can be assessed by plating such cell population over a living base layer of normal liver cells.
    Citation
    Identification of transformed rat liver epithelial cells in culture. 1979, 6 (1):27-32 Cancer Lett
    Journal
    Cancer Letters
    URI
    http://hdl.handle.net/10541/135772
    DOI
    10.1016/S0304-3835(79)80016-6
    PubMed ID
    544009
    Type
    Article
    Language
    en
    ISSN
    0304-3835
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0304-3835(79)80016-6
    Scopus Count
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    All Paterson Institute for Cancer Research

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