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    Alkylation of DNA and carcinogenicity of N-nitroso compounds.

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    Authors
    Montesano, R
    Pegg, A
    Margison, Geoffrey P
    Issue Date
    1980
    
    Metadata
    Show full item record
    Abstract
    The possible mode of action of two classes of highly organ- and species-specific carcinogenic N-nitroso compounds, namely the N-nitrosamines and N-nitrosamides, is outlined in this review. Chemical or enzymatic conversion of these agents into active alkylating species is a prerequisite for their biological activity. Although these species are capable of reacting with all cellular macromolecules, there is good evidence that their ability to attack DNA is related to their carcinogenicity. This paper reviews the reasons and experimental support for the hypothesis that it is specifically alkylation of DNA at the O6 position of guanine that initiates malignant transformation, an important factor being the presence of an enzyme system capable of eliminating O6-alkylguanine from DNA. No such repair reaction appears to exist for this or other alkylation products when they are present in RNA. The activity of this system is enhanced by chronic administration of alkylating agents, and the role that this may play in carcinogenesis is discussed.
    Citation
    Alkylation of DNA and carcinogenicity of N-nitroso compounds. 1980, 6 (5-6):1001-8 J Toxicol Environ Health
    Journal
    Journal of Toxicology and Environmental Health
    URI
    http://hdl.handle.net/10541/135530
    DOI
    10.1080/15287398009529922
    PubMed ID
    6162032
    Type
    Article
    Language
    en
    ISSN
    0098-4108
    ae974a485f413a2113503eed53cd6c53
    10.1080/15287398009529922
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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