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dc.contributor.authorWilkinson, John M
dc.contributor.authorHendry, Jolyon H
dc.contributor.authorHunter, Robin D
dc.date.accessioned2011-07-04T11:10:14Z
dc.date.available2011-07-04T11:10:14Z
dc.date.issued1980-09
dc.identifier.citationDose-rate considerations in the introduction of low-dose-rate afterloading intracavitary techniques for radiotherapy. 1980, 53 (633):890-3 Br J Radiolen
dc.identifier.issn0007-1285
dc.identifier.pmid7437712
dc.identifier.doi10.1259/0007-1285-53-633-890
dc.identifier.urihttp://hdl.handle.net/10541/135257
dc.description.abstractAn investigation has been made into the changes in total dose required as a consequence of proposed increases in dose-rate in low-dose-rate treatments of cancer of the uterine cervix. The relationship between total irradiation time and dose-rate has been measured using an assay based on mouse-tail radionecrosis, with irradiation schedules similar to existing and proposed human cervix treatments. This relationship, which is similar to that observed in other biological systems, predicts that the total dose for epithelial tolerance should be reduced by about one third when the dose-rate is increased from 1.0 to 3.5 Gy per hour. The clinical implications of this finding are discussed.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshBrachytherapy
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshMice
dc.subject.meshNecrosis
dc.subject.meshRadiation Injuries, Experimental
dc.subject.meshRadiotherapy Dosage
dc.subject.meshSkin
dc.subject.meshTail
dc.titleDose-rate considerations in the introduction of low-dose-rate afterloading intracavitary techniques for radiotherapy.en
dc.typeArticleen
dc.contributor.departmentDepartments of Physics and Radiotherapy, and Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BXen
dc.identifier.journalBritish Journal of Radiologyen
html.description.abstractAn investigation has been made into the changes in total dose required as a consequence of proposed increases in dose-rate in low-dose-rate treatments of cancer of the uterine cervix. The relationship between total irradiation time and dose-rate has been measured using an assay based on mouse-tail radionecrosis, with irradiation schedules similar to existing and proposed human cervix treatments. This relationship, which is similar to that observed in other biological systems, predicts that the total dose for epithelial tolerance should be reduced by about one third when the dose-rate is increased from 1.0 to 3.5 Gy per hour. The clinical implications of this finding are discussed.


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