Dose-rate considerations in the introduction of low-dose-rate afterloading intracavitary techniques for radiotherapy.
Affiliation
Departments of Physics and Radiotherapy, and Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BXIssue Date
1980-09
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Show full item recordAbstract
An investigation has been made into the changes in total dose required as a consequence of proposed increases in dose-rate in low-dose-rate treatments of cancer of the uterine cervix. The relationship between total irradiation time and dose-rate has been measured using an assay based on mouse-tail radionecrosis, with irradiation schedules similar to existing and proposed human cervix treatments. This relationship, which is similar to that observed in other biological systems, predicts that the total dose for epithelial tolerance should be reduced by about one third when the dose-rate is increased from 1.0 to 3.5 Gy per hour. The clinical implications of this finding are discussed.Citation
Dose-rate considerations in the introduction of low-dose-rate afterloading intracavitary techniques for radiotherapy. 1980, 53 (633):890-3 Br J RadiolJournal
British Journal of RadiologyDOI
10.1259/0007-1285-53-633-890PubMed ID
7437712Type
ArticleLanguage
enISSN
0007-1285ae974a485f413a2113503eed53cd6c53
10.1259/0007-1285-53-633-890