Which are the leukaemic cells?
| dc.contributor.author | Lajtha, L G | |
| dc.date.accessioned | 2011-07-04T11:09:20Z | |
| dc.date.available | 2011-07-04T11:09:20Z | |
| dc.date.issued | 1981 | |
| dc.identifier.citation | Which are the leukaemic cells? 1981, 7 (1):45-62 Blood Cells | en |
| dc.identifier.issn | 0340-4684 | |
| dc.identifier.pmid | 7187748 | |
| dc.identifier.uri | http://hdl.handle.net/10541/135256 | |
| dc.description.abstract | Two features are known about acute myeloid leukaemia in man: (1) the long time-scale from identifiable leukaemogenic stimulus and onset of the clinical disease and (2) the successful induction and duration of long clinical remission. These indicate three probabilities: First, that the target cell for leukaemogenetic insult (in AML) is the pluripotent stem cell; second, that the leukaemic stem line is a small minority population within the total leukaemic cell mass; third, when the leukaemic stem line is not greatly exceeding the normal stem cell numbers, its proliferation may be still under partial control. | |
| dc.language.iso | en | en |
| dc.subject | Leukaemia | en |
| dc.subject.mesh | Animals | |
| dc.subject.mesh | Cell Differentiation | |
| dc.subject.mesh | Cell Division | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Leukemia | |
| dc.subject.mesh | Neoplastic Stem Cells | |
| dc.title | Which are the leukaemic cells? | en |
| dc.contributor.department | Paterson Laboratories, CHristie Hospital and Holt Radium Institute, Withington, Manchester, M20 9BX, UK | en |
| dc.identifier.journal | Blood Cells | en |
| html.description.abstract | Two features are known about acute myeloid leukaemia in man: (1) the long time-scale from identifiable leukaemogenic stimulus and onset of the clinical disease and (2) the successful induction and duration of long clinical remission. These indicate three probabilities: First, that the target cell for leukaemogenetic insult (in AML) is the pluripotent stem cell; second, that the leukaemic stem line is a small minority population within the total leukaemic cell mass; third, when the leukaemic stem line is not greatly exceeding the normal stem cell numbers, its proliferation may be still under partial control. |