• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Which are the leukaemic cells?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Lajtha, L G
    Affiliation
    Paterson Laboratories, CHristie Hospital and Holt Radium Institute, Withington, Manchester, M20 9BX, UK
    Issue Date
    1981
    
    Metadata
    Show full item record
    Abstract
    Two features are known about acute myeloid leukaemia in man: (1) the long time-scale from identifiable leukaemogenic stimulus and onset of the clinical disease and (2) the successful induction and duration of long clinical remission. These indicate three probabilities: First, that the target cell for leukaemogenetic insult (in AML) is the pluripotent stem cell; second, that the leukaemic stem line is a small minority population within the total leukaemic cell mass; third, when the leukaemic stem line is not greatly exceeding the normal stem cell numbers, its proliferation may be still under partial control.
    Citation
    Which are the leukaemic cells? 1981, 7 (1):45-62 Blood Cells
    Journal
    Blood Cells
    URI
    http://hdl.handle.net/10541/135256
    PubMed ID
    7187748
    Language
    en
    ISSN
    0340-4684
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Generation time of leukaemic blast progenitor cells.
    • Authors: Minden M, Major P, Griffin J, Wu A, Kufe D
    • Issue date: 1983 Nov
    • Lack of expression of the chondroitin sulphate proteoglycan neuron-glial antigen 2 on candidate stem cell populations in paediatric acute myeloid leukaemia/abn(11q23) and acute lymphoblastic leukaemia/t(4;11).
    • Authors: Neudenberger J, Hotfilder M, Rosemann A, Langebrake C, Reinhardt D, Pieters R, Schrauder A, Schrappe M, Röttgers S, Harbott J, Vormoor J
    • Issue date: 2006 May
    • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.
    • Authors: Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA
    • Issue date: 2006 Aug 17
    • Relapse after allogeneic BMT for chronic myeloid leukemia (CML) may be sustained by a small number of leukemic 'stem cells': a hypothesis.
    • Authors: Frassoni F, Podestà M, Piaggio G, Pitto A, Figari O, Soracco M, Lint M, Fugazza G, Sessarego M, Bacigalupo A
    • Issue date: 1999 Sep
    • Human leukaemic stem cells: a novel target of therapy.
    • Authors: Sperr WR, Hauswirth AW, Florian S, Ohler L, Geissler K, Valent P
    • Issue date: 2004 Aug
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.