Authors
Lajtha, L GAffiliation
Paterson Laboratories, CHristie Hospital and Holt Radium Institute, Withington, Manchester, M20 9BX, UKIssue Date
1981
Metadata
Show full item recordAbstract
Two features are known about acute myeloid leukaemia in man: (1) the long time-scale from identifiable leukaemogenic stimulus and onset of the clinical disease and (2) the successful induction and duration of long clinical remission. These indicate three probabilities: First, that the target cell for leukaemogenetic insult (in AML) is the pluripotent stem cell; second, that the leukaemic stem line is a small minority population within the total leukaemic cell mass; third, when the leukaemic stem line is not greatly exceeding the normal stem cell numbers, its proliferation may be still under partial control.Citation
Which are the leukaemic cells? 1981, 7 (1):45-62 Blood CellsJournal
Blood CellsPubMed ID
7187748Language
enISSN
0340-4684Collections
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