Analysis of the steepness of the dose-incidence curve for necrosis in mouse tails after a multifraction x-ray schedule.
AuthorsHendry, Jolyon H
AffiliationPaterson Laboratories, Christie Hospital and Holt Radium Institute, Withington, Manchester M20 9BX Great Britain
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AbstractThe steepness of the dose-incidence curve for necrosis of mouse tails was measured in detail after a multifractionated schedule of 15 fractions over 19 days. The steepness is compared with curves reported previously for some other rodent and human tissues, and it is analyzed in terms of a composite mean lethal dose for the fractionated treatment of the target cells envisaged as responsible for tail necrosis. It is shown that this dose of 2.3 +/- 0.3 Gy (230 +/- 30 rad) is equivalent to the inverse slope of the tangent to the survival curve for single doses, at the mean dose fraction used of 4.3 Gy (430 rad).
CitationAnalysis of the steepness of the dose-incidence curve for necrosis in mouse tails after a multifraction x-ray schedule. 1980, 134 (3):757-62 Radiology
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