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    Malignant myelomonocytic cells after in vitro infection of marrow cells with Friend leukaemia virus.

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    Authors
    Testa, Nydia G
    Dexter, T Michael
    Scott, David
    Teich, N M
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1980-01
    
    Metadata
    Show full item record
    Abstract
    Infection of long-term BDF1 marrow cultures with Friend leukaemia virus complex (FLV) induced transformed cells with myelomonocytic characteristics, which were isolated only 14 days after the viral infection. Criteria for transformation were growth in suspension cultures and high plating efficiency in agar. The lymphatic leukaemia virus (LLV) replicates in these suspension cultures, but the spleen focus-forming virus (SFFV) component of the FLV complex has not been detected. Injection of the transformed cells into syngeneic neonatal or adult mice leads to the development of leukaemia which can be demonstrated to be of donor origin by the presence of two metacentric marker chromosomes which are also seen in the cultured cells.
    Citation
    Malignant myelomonocytic cells after in vitro infection of marrow cells with Friend leukaemia virus. 1980, 41 (1):33-9 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/134896
    PubMed ID
    6928787
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

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