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dc.contributor.authorHarrison, Christine J
dc.contributor.authorConnell, J R
dc.contributor.authorAllen, Terence D
dc.contributor.authorOckey, Charles H
dc.date.accessioned2011-06-29T17:31:18Z
dc.date.available2011-06-29T17:31:18Z
dc.date.issued1980-07
dc.identifier.citationChanges in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells. 1980, 42 (1):103-11 Br J Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid6775654
dc.identifier.urihttp://hdl.handle.net/10541/134895
dc.description.abstractThe relationship between ageing and transformation has been investigated by a serial study of the changes in cell-surface morphology as normal and carcinogen-treated cells progressed in culture. A progressive increase in the density of cell surface microvilli occurred in association with the adoption of a more rounded profile and concomitant increase in the rate of cell detachment. These changes occurred earlier after carcinogen treatment, which appeared to indicate a carcinogen-induced acceleration of ageing. The alterations have also been described as characteristic of the transformed state. The observations suggest that the expression of in vitro transformation may be the result of continuous selection from a population with genetic instability and variable morphology.
dc.language.isoenen
dc.subject.mesh9,10-Dimethyl-1,2-benzanthracene
dc.subject.meshAnimals
dc.subject.meshBenzopyrenes
dc.subject.meshCarcinogens
dc.subject.meshCell Membrane
dc.subject.meshCell Survival
dc.subject.meshCell Transformation, Neoplastic
dc.subject.meshCells, Cultured
dc.subject.meshCricetinae
dc.subject.meshCricetulus
dc.subject.meshLung
dc.subject.meshMethylnitronitrosoguanidine
dc.subject.meshMicroscopy, Electron, Scanning
dc.subject.meshTime Factors
dc.titleChanges in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchesteren
dc.identifier.journalBritish Journal of Canceren
html.description.abstractThe relationship between ageing and transformation has been investigated by a serial study of the changes in cell-surface morphology as normal and carcinogen-treated cells progressed in culture. A progressive increase in the density of cell surface microvilli occurred in association with the adoption of a more rounded profile and concomitant increase in the rate of cell detachment. These changes occurred earlier after carcinogen treatment, which appeared to indicate a carcinogen-induced acceleration of ageing. The alterations have also been described as characteristic of the transformed state. The observations suggest that the expression of in vitro transformation may be the result of continuous selection from a population with genetic instability and variable morphology.


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