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    Collagenase immunolocalization studies of cutaneous secondary melanomas.

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    Authors
    Woolley, D E
    Grafton, C A
    Affiliation
    University Department of Medicine, University Hospital of South Manchester
    Issue Date
    1980-08
    
    Metadata
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    Abstract
    Immunoreactive collagenase has been demonstrated in 5/14 specimens of cutaneous secondary melanomas. In contrast, very little enzyme was seen in 10 specimens of normal human skin. All specimens were fixed within minutes of excision. These findings support the hypothesis that collagenase facilitates connective-tissue breakdown which is associated with tumour invasiveness and metastatic spread.
    Citation
    Collagenase immunolocalization studies of cutaneous secondary melanomas. 1980, 42 (2):260-5 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/134894
    PubMed ID
    6252926
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

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