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    Enhancement of human natural cell-mediated cytotoxicity by interferon.

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    Authors
    Moore, Michael
    Potter, M R
    Affiliation
    Immunology Division, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX
    Issue Date
    1980-03
    
    Metadata
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    Abstract
    The effect of exogenous Namalva interferon (IF) on the natural killer (NK) cell activity of human blood lymphocytes was examined against 5 target cell lines (K562, CCRF/CEM, Molt 4, Raji and Bri8) using the 51Cr-release assay. Addition of IF to the test significantly increased the cytotoxicity, though not as much as when effector cells were treated with IF before the test. Augmentation of cytotoxicity was evident after only 1 h pretreatment and was maximal by 6 h. The rate of lysis of susceptible targets by IF-treated effectors markedly exceeded that by their untreated counterparts. Separation of lymphocyte subpopulations (by SRBC-rosette sedimentation and nylon-fibre column filtration) demonstrated that the activities of IF-stimulated and unstimulated cells were similarly distributed, suggesting that the major effect of IF is enhancement of the activity of pre-existing NK cells rather than generation of new populations of effectors. Target cell lines with high and low susceptibility to NK cells showed increased cytotoxicity by IF-treated effector cells. These findings may be relevant to the current discussion of the role of NK cells in immunosurveillance against neoplasia.
    Citation
    Enhancement of human natural cell-mediated cytotoxicity by interferon. 1980, 41 (3):378-87 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/134893
    PubMed ID
    6155926
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

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