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    Survival of intestinal crypts after treatment by adriamycin alone or with radiation.

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    Authors
    Moore, James V
    Broadbent, D A
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1980-11
    
    Metadata
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    Abstract
    A survival curve has been established for jejunal crypts of BDF1 mice treated by single i.p. doses of the antibiotic agent adriamycin. The threshold dose and Do were twice that for marrow CFU-S of these mice. The overall extrapolation number of the crypt survival curve was very low (1.3 +/- 0.13) compared to the value for gamma radiation. This observation is discussed with respect to the interpretation of crypt survival curves. We were unable to demonstrate any enhancement by adriamycin (reduction in Dq) of the response of microcolony-forming cells to radiation given immediately before the drug.
    Citation
    Survival of intestinal crypts after treatment by adriamycin alone or with radiation. 1980, 42 (5):692-6 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/134892
    PubMed ID
    7459206
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

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