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    Dynamic histology of a rat hepatoma and the response to 5-fluorouracil.

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    Authors
    Moore, James V
    Hopkins, H A
    Looney, W B
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, England
    Issue Date
    1980-01
    
    Metadata
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    Abstract
    The cellular response of the rat hepatoma 3924A to a single intraperitoneal injection of 5-fluorouracil has been measured in respect of the spatial relationship of the cells to the tumour microvasculature. In this tumour the parenchyma is arranged in cords approximately 150 micron thick around central capillaries. For untreated tumours, those cells at distance less than 80 micron from the capillary had a mean [3HTdR labelling index of 39% and a mitotic index of 2.1%, while for those cells more than 80 micron away the values were 14% and 0.8% respectively. Two days after 150 mg/kg of 5-fluorouracil, mean cord thickness was reduced by 25% and did not recover to the control level until 11 days after treatment. This was also true for the mitotic index. Recovery of the labelling index was complete 2 days earlier. Although absolute values of parameters were different in the populations adjacent to and remote from the capillary, the time course of recovery was similar, with a 'growth spur' 7 to 9 days after treatment. The results from this histologically-based assay have been compared with those from biochemical/biophysical assays that sample the overall tumour population.
    Citation
    Dynamic histology of a rat hepatoma and the response to 5-fluorouracil. 1980, 13 (1):53-63 Cell Tissue Kinet
    Journal
    Cell and Tissue Kinetics
    URI
    http://hdl.handle.net/10541/134862
    DOI
    10.1111/j.1365-2184.1980.tb00449.x
    PubMed ID
    7371059
    Type
    Article
    Language
    en
    ISSN
    0008-8730
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2184.1980.tb00449.x
    Scopus Count
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    All Paterson Institute for Cancer Research

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