An experimental model for selective inhibition of proliferating cells by chemotherapeutic agents.
AuthorsNaha, P M
AffiliationPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, U.K
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AbstractConditionally transformable cells of primate origin in which 'untransformed' and 'transformed' cells derived from the same source grow in culture, has been used as an experimental system for testing selective inhibition of proliferating cells by chemotherapeutic agents. The cytotoxic agents Adriamycin and Mitomycin C fail to recognise "tumour cells" in a heterogenous population and thus differ from the non-toxic and non-carcinogenic agent L-canavanine.
CitationAn experimental model for selective inhibition of proliferating cells by chemotherapeutic agents. 1980, 4 (9):829-39 Cell Biol. Int. Rep.
JournalCell Biology International Reports
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