An experimental model for selective inhibition of proliferating cells by chemotherapeutic agents.
AuthorsNaha, P M
AffiliationPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, U.K
MetadataShow full item record
AbstractConditionally transformable cells of primate origin in which 'untransformed' and 'transformed' cells derived from the same source grow in culture, has been used as an experimental system for testing selective inhibition of proliferating cells by chemotherapeutic agents. The cytotoxic agents Adriamycin and Mitomycin C fail to recognise "tumour cells" in a heterogenous population and thus differ from the non-toxic and non-carcinogenic agent L-canavanine.
CitationAn experimental model for selective inhibition of proliferating cells by chemotherapeutic agents. 1980, 4 (9):829-39 Cell Biol. Int. Rep.
JournalCell Biology International Reports
- Reappraisal of L-canavanine as an anti-tumour agent.
- Authors: Naha PM, Silcock JM, Fellows L
- Issue date: 1980 Feb
- Effects of chemotherapeutic agents on alpha-fetoprotein secretion and growth of human hepatoma cell lines in vitro.
- Authors: Muraoka A, Tokiwa T, Sato J
- Issue date: 1989 Apr
- [Chemosensitivity of adriamycin, mitomycin C, and bleomycin with in vitro colony assay].
- Authors: Miyamoto H, Inoue K, Arakawa M, Ogawa M
- Issue date: 1982 Nov
- [Effect of a calcium influx blocker, verapamil, on the sensitivity of human bladder cancer cells to adriamycin and mitomycin C].
- Authors: Kageyama Y, Kihara K, Ohta S, Yoshida K
- Issue date: 1988 May
- L-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines.
- Authors: Worthen DR, Chien L, Tsuboi CP, Mu XY, Bartik MM, Crooks PA
- Issue date: 1998 Oct 23