Show simple item record

dc.contributor.authorKimber, I
dc.contributor.authorMoore, Michael
dc.date.accessioned2011-06-29T13:00:39Z
dc.date.available2011-06-29T13:00:39Z
dc.date.issued1981
dc.identifier.citationSelective enhancement of human mononuclear leucocyte cytotoxic function by interferon. 1981, 13 (4):375-81 Scand J Immunolen
dc.identifier.issn0300-9475
dc.identifier.pmid6171028
dc.identifier.doi10.1111/j.1365-3083.1981.tb00147.x
dc.identifier.urihttp://hdl.handle.net/10541/134852
dc.description.abstractThe influence of type I interferon (IFN) on leucocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) has been examined in a system in which differential alloantibody sensitization of human erythrocyte target cells allows discrimination between lymphocyte and monocyte effector function. ADCC mediated by unfractionated mononuclear leucocyte populations was regularly enhanced by interferon pretreatment over a range of concentrations of the sensitizing antibody. The capacity of IFN-augmented reactivity was, however, removed with adherent cell depletion, suggesting that lymphocyte (K-cell) effectors are not modulated by IFN, even though such populations demonstrate IFN-potentiated natural killer (NK) reactivity against K562. These results suggest that monocyte and NK cell function but not K-cell activity was influenced by interferon.
dc.language.isoenen
dc.subject.meshAntibody-Dependent Cell Cytotoxicity
dc.subject.meshCytotoxicity Tests, Immunologic
dc.subject.meshErythrocytes
dc.subject.meshHemolysis
dc.subject.meshHumans
dc.subject.meshInterferons
dc.subject.meshIsoantibodies
dc.subject.meshKiller Cells, Natural
dc.subject.meshLeukocytes
dc.titleSelective enhancement of human mononuclear leucocyte cytotoxic function by interferon.en
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, UKen
dc.identifier.journalScandinavian Journal of Immunologyen
html.description.abstractThe influence of type I interferon (IFN) on leucocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) has been examined in a system in which differential alloantibody sensitization of human erythrocyte target cells allows discrimination between lymphocyte and monocyte effector function. ADCC mediated by unfractionated mononuclear leucocyte populations was regularly enhanced by interferon pretreatment over a range of concentrations of the sensitizing antibody. The capacity of IFN-augmented reactivity was, however, removed with adherent cell depletion, suggesting that lymphocyte (K-cell) effectors are not modulated by IFN, even though such populations demonstrate IFN-potentiated natural killer (NK) reactivity against K562. These results suggest that monocyte and NK cell function but not K-cell activity was influenced by interferon.


This item appears in the following Collection(s)

Show simple item record