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    Selective enhancement of human mononuclear leucocyte cytotoxic function by interferon.

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    Authors
    Kimber, I
    Moore, Michael
    Affiliation
    Department of Immunology, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, UK
    Issue Date
    1981
    
    Metadata
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    Abstract
    The influence of type I interferon (IFN) on leucocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) has been examined in a system in which differential alloantibody sensitization of human erythrocyte target cells allows discrimination between lymphocyte and monocyte effector function. ADCC mediated by unfractionated mononuclear leucocyte populations was regularly enhanced by interferon pretreatment over a range of concentrations of the sensitizing antibody. The capacity of IFN-augmented reactivity was, however, removed with adherent cell depletion, suggesting that lymphocyte (K-cell) effectors are not modulated by IFN, even though such populations demonstrate IFN-potentiated natural killer (NK) reactivity against K562. These results suggest that monocyte and NK cell function but not K-cell activity was influenced by interferon.
    Citation
    Selective enhancement of human mononuclear leucocyte cytotoxic function by interferon. 1981, 13 (4):375-81 Scand J Immunol
    Journal
    Scandinavian Journal of Immunology
    URI
    http://hdl.handle.net/10541/134852
    DOI
    10.1111/j.1365-3083.1981.tb00147.x
    PubMed ID
    6171028
    Type
    Article
    Language
    en
    ISSN
    0300-9475
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-3083.1981.tb00147.x
    Scopus Count
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    All Paterson Institute for Cancer Research

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