• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Measuring partial thromboplastin-time. An international collaborative study.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Poller, L
    Thomson, J
    Palmer, Michael K
    Affiliation
    World Health Organisation Collaborating Centre for Anticoagulant Control Reagents, Haematology Department, Withington Hospital, Manchester M20 8LR, United Kingdom
    Issue Date
    1976-10-16
    
    Metadata
    Show full item record
    Abstract
    A series of collaborative exercises on the partial thromboplastin-time (P.T.T.) test, involving over three hundred hospital centres in Britain and overseas, were performed in 1975. Lyophilised test plasmas were issued from the World Health Organisation Collaborating Centre for Anticoagulant Control Reagents to participants, together with a standardised reference P.T.T. reagent and a standard technique. Hospitals were asked to test the plasma samples with the standardised reagent and technique in parallel with their customary local P.T.T. reagent and method. The overall success-rate in detecting the intrinsic clotting abnormality in the eight abnormal test samples was higher with the standardised reagent and technique than with all other reagents. Furthermore, fewer hospitals obtained false positive results when the normal plasma sample was tested with the standardised method rather than with their usual routine reagents. An index was used to measure the success-rate of the P.T.T. reagents in correctly identifying the test plasmas as normal or abnormal. The eight test plasmas showed a varying degree of abnormality. A system of "weighting" was therefore introduced as the failure of a P.T.T. method to detect more severe defects was regarded as more serious. Although hospitals were unfamiliar with the standardised method, the results established its superiority over all other P.T.T. reagents included in the trials in sufficient numbers for analysis. Failures with commercial reagents may have been caused by insensitivity of the cephalin extracts or the unreliability of the manufacturers recommended techniques. Since the same laboratories obtained good results with the standardised method technical failure can be excluded.
    Citation
    Measuring partial thromboplastin-time. An international collaborative study. 1976, 2 (7990):842-6 Lancet
    Journal
    Lancet
    URI
    http://hdl.handle.net/10541/134314
    DOI
    10.1016/S0140-6736(76)91224-1
    PubMed ID
    61512
    Type
    Article
    Language
    en
    ISSN
    0140-6736
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0140-6736(76)91224-1
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Standardization of the APTT test. Current status.
    • Authors: Poller L
    • Issue date: 1980
    • Activated partial thromboplastin time. A multicenter evaluation of 11 reagents in the screening of mild haemophilia A.
    • Issue date: 1980 Oct
    • Comparison of the sensitivity of commercial APTT reagents in the detection of mild coagulopathies.
    • Authors: Marlar RA, Bauer PJ, Endres-Brooks JL, Montgomery RR, Miller CM, Schanen MM
    • Issue date: 1984 Oct
    • The control of heparin therapy by the activated partial thromboplastin time: results of collaborative studies.
    • Authors: Thomson JM
    • Issue date: 1980
    • Quality control trials of prothrombin time: an assessment of the performance in serial studies.
    • Authors: Poller L, Thomson JM, Yee KF
    • Issue date: 1979 Mar
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.