Effect of low dose ionizing radiation on the murine pericryptal fibroblast sheath: radiation damage in a mesenchymal system in vivo.
| dc.contributor.author | Neal, J Valerie | |
| dc.contributor.author | Potten, Christopher S | |
| dc.date.accessioned | 2011-06-23T16:30:27Z | |
| dc.date.available | 2011-06-23T16:30:27Z | |
| dc.date.issued | 1981-02 | |
| dc.identifier.citation | Effect of low dose ionizing radiation on the murine pericryptal fibroblast sheath: radiation damage in a mesenchymal system in vivo. 1981, 39 (2):175-83 Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | en |
| dc.identifier.issn | 0020-7616 | |
| dc.identifier.pmid | 6971829 | |
| dc.identifier.doi | 10.1080/09553008114550191 | |
| dc.identifier.uri | http://hdl.handle.net/10541/134312 | |
| dc.description.abstract | The effect of low dose ionizing radiation from a variety of sources on the murine small intestinal and colonic pericryptal fibroblast sheath (PCFS) has been investigated. Ultrastructural and light microscopic changes seen within 3 hours after radiation resembles the mode of cell death known as apoptosis. The apoptotic index (AI) was shown to rise steadily for 4 hours after irradiation, and then to return to control levels by 10 hours. 137Cs gamma-irradiation over a range of doses from 0-803 cGy caused an increase in AI from control values of 1-2 per cent to a plateau level of approximately 8.5 per cent for doses above 40 cGy. Investigation of the response of the PCFS to doses of 137Cs and 60Co gamma-irradiation and X-irradiation below 40 cGy demonstrated a steady increase with dose in AI. The survival curve for the radiosensitive subpopulation susceptible to death through apoptosis as a consequence of exposure to non-acute doses of radiation has a D0 of 10.6 cGy and an extrapolation number of 2.3. | |
| dc.language.iso | en | en |
| dc.subject.mesh | Animals | |
| dc.subject.mesh | Cell Survival | |
| dc.subject.mesh | Cesium Radioisotopes | |
| dc.subject.mesh | Cobalt Radioisotopes | |
| dc.subject.mesh | Colon | |
| dc.subject.mesh | Dose-Response Relationship, Radiation | |
| dc.subject.mesh | Female | |
| dc.subject.mesh | Fibroblasts | |
| dc.subject.mesh | Gamma Rays | |
| dc.subject.mesh | Intestine, Small | |
| dc.subject.mesh | Male | |
| dc.subject.mesh | Mice | |
| dc.subject.mesh | Mice, Inbred DBA | |
| dc.subject.mesh | X-Rays | |
| dc.title | Effect of low dose ionizing radiation on the murine pericryptal fibroblast sheath: radiation damage in a mesenchymal system in vivo. | en |
| dc.type | Article | en |
| dc.contributor.department | Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, England | en |
| dc.identifier.journal | International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine | en |
| html.description.abstract | The effect of low dose ionizing radiation from a variety of sources on the murine small intestinal and colonic pericryptal fibroblast sheath (PCFS) has been investigated. Ultrastructural and light microscopic changes seen within 3 hours after radiation resembles the mode of cell death known as apoptosis. The apoptotic index (AI) was shown to rise steadily for 4 hours after irradiation, and then to return to control levels by 10 hours. 137Cs gamma-irradiation over a range of doses from 0-803 cGy caused an increase in AI from control values of 1-2 per cent to a plateau level of approximately 8.5 per cent for doses above 40 cGy. Investigation of the response of the PCFS to doses of 137Cs and 60Co gamma-irradiation and X-irradiation below 40 cGy demonstrated a steady increase with dose in AI. The survival curve for the radiosensitive subpopulation susceptible to death through apoptosis as a consequence of exposure to non-acute doses of radiation has a D0 of 10.6 cGy and an extrapolation number of 2.3. |