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    Lysis of alloantibody-sensitized human erythrocytes by peripheral blood mononuclear cells: heterogeneity of effector populations.

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    Authors
    Kimber, Ian
    Moore, Michael
    Issue Date
    1981-01
    
    Metadata
    Show full item record
    Abstract
    Cell-mediated haemolysis of human erythrocytes (HRBC) mediated by sensitizing alloantibodies of two specificities was studied using the 51Cr release assay. Peripheral blood mononuclear cells (PBMC) were found capable fo lysing HRBC of phenotype ARh(D) + ve sensitized with either anti-D or "natural" anti-A antibodies. The characteristics of the effector population, however, were dependent upon the sensitizing antibody. HRBC sensitized with anti-A were lysed by a radioresistant, silica- and carrageenan-sensitive population which could be selectively removed by adherence. Sensitization with rhesus antibody induced cytotoxicity by a population which was radiosensitive and relatively unaffected by removal of adherent cells or by treatment with silica or carrageenan. The results demonstrate that the antigen-antibody interaction, rather than the target cell type, determines which effector cells participate in antibody-dependent cellular cytotoxicity (ADCC) against human red cells.
    Citation
    Lysis of alloantibody-sensitized human erythrocytes by peripheral blood mononuclear cells: heterogeneity of effector populations. 1981, 5 (1):41-6 J Clin Lab Immunol
    Journal
    Journal of Clinical & Laboratory Immunology
    URI
    http://hdl.handle.net/10541/134309
    PubMed ID
    6260947
    Type
    Article
    Language
    en
    ISSN
    0141-2760
    Collections
    All Paterson Institute for Cancer Research

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