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    Pretreatment of Chinese hamster v79 cells with MNU increases survival without affecting DNA repair or mutagenicity.

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    Authors
    Durrant, Linda G
    Margison, Geoffrey P
    Boyle, John M
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, manchester, M20 9BX, UK
    Issue Date
    1981
    
    Metadata
    Show full item record
    Abstract
    Exposure of Chinese hamster V79 cells to a non-toxic dose of N-methyl-N-nitrosourea, followed at intervals by exposure to toxic challenging doses of the same agent, resulted in increased survival of colony forming ability when these cells were compared with matched control cells that only received the challenging dose. The extent of the increase was dependent on the time interval between exposures, and rose to a maximum of about two-fold 5 days after the initial dose, declining slowly to control values on subsequent days. Whilst pretreatment enhanced survival, it altered neither the frequency of mutation to 6-thioguanine resistance, nor the formation or loss of 3-methyladenine, 7-methylguanine and O6-methylguanine. Modification of the conditions by which the initial dose was administered led to a reduction or abolition of the survival response. It is suggested that enhanced survival may result from alteration in the ability to recover from cellular damage rather than by improved DNA repair.
    Citation
    Pretreatment of Chinese hamster v79 cells with MNU increases survival without affecting DNA repair or mutagenicity. 1981, 2 (1):55-60 Carcinogenesis
    Journal
    Carcinogenesis
    URI
    http://hdl.handle.net/10541/134191
    DOI
    10.1093/carcin/2.1.55
    PubMed ID
    7273289
    Type
    Article
    Language
    en
    ISSN
    0143-3334
    ae974a485f413a2113503eed53cd6c53
    10.1093/carcin/2.1.55
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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