Show simple item record

dc.contributor.authorNeal, J Valerie
dc.contributor.authorPotten, Christopher S
dc.date.accessioned2011-06-22T09:08:19Z
dc.date.available2011-06-22T09:08:19Z
dc.date.issued1981-09
dc.identifier.citationPolyploidy in the murine colonic pericryptal fibroblast sheath. 1981, 14 (5):527-36 Cell Tissue Kineten
dc.identifier.issn0008-8730
dc.identifier.pmid7273094
dc.identifier.doi10.1111/j.1365-2184.1981.tb00558.x
dc.identifier.urihttp://hdl.handle.net/10541/134135
dc.description.abstractThe cause of the apparently paradoxical occurrence of relatively high levels of labelling and low levels of mitotic activity in the pericryptal fibroblast sheath (PCFS) was investigated. Analysis of the distribution of grain densities over epithelial cells and the PCFS in the colon demonstrated that, although the former had a unimodal peak, the PCFS had a multi-peak distribution. The PCFS nuclei with the higher grain densities gradually disappeared with time, due not to proliferation but to lateral migration into the lamina propria. Photodensitometric analysis confirmed the existence of polyploid cells in the colonic PCFS, but not in the epithelium.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Nucleus
dc.subject.meshColon
dc.subject.meshEpithelial Cells
dc.subject.meshFibroblasts
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshPolyploidy
dc.titlePolyploidy in the murine colonic pericryptal fibroblast sheath.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital & Holt Radium Institute, Manchesteren
dc.identifier.journalCell and Tissue Kineticsen
html.description.abstractThe cause of the apparently paradoxical occurrence of relatively high levels of labelling and low levels of mitotic activity in the pericryptal fibroblast sheath (PCFS) was investigated. Analysis of the distribution of grain densities over epithelial cells and the PCFS in the colon demonstrated that, although the former had a unimodal peak, the PCFS had a multi-peak distribution. The PCFS nuclei with the higher grain densities gradually disappeared with time, due not to proliferation but to lateral migration into the lamina propria. Photodensitometric analysis confirmed the existence of polyploid cells in the colonic PCFS, but not in the epithelium.


This item appears in the following Collection(s)

Show simple item record