Gross and cellular response of intestinal crypts to single and fractionated doses of vincristine plus radiation: the influence of time between modalities.
| dc.contributor.author | Moore, James V | |
| dc.contributor.author | Pearson, D | |
| dc.contributor.author | Deakin, David P | |
| dc.date.accessioned | 2011-06-21T16:47:41Z | |
| dc.date.available | 2011-06-21T16:47:41Z | |
| dc.date.issued | 1982-09 | |
| dc.identifier.citation | Gross and cellular response of intestinal crypts to single and fractionated doses of vincristine plus radiation: the influence of time between modalities. 1982, 42 (3):305-16 Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | en |
| dc.identifier.issn | 0020-7616 | |
| dc.identifier.pmid | 6982881 | |
| dc.identifier.doi | 10.1080/09553008214551221 | |
| dc.identifier.uri | http://hdl.handle.net/10541/134096 | |
| dc.description.abstract | The response of intestinal crypts to single doses and four equal, daily fractions of vincristine (VCR) plus gamma-rays, has been measured by the crypt microcolony assay. Measurements were made for VCR given either 7 hours or 1 min before radiation. For the 7-hour interval, fractionating the VCR dose markedly increased the efficacy of the combination treatment. However at 1-min interval, no injury additional to that for gamma-rays alone could be demonstrated, with either one or four fractions. Histopathological studies showed that both VCR and gamma-rays alone caused cell death, but with different distributions in the crypt. For combined treatments, both VCR-and gamma-type damage could be recognized with the 7-hour interval, but at 1 min only gamma damage. It is suggested that mitotic delay induced by radiation may permit the repair of injury caused by simultaneously-delivered VCR. | |
| dc.language.iso | en | en |
| dc.subject.mesh | Animals | |
| dc.subject.mesh | Cell Survival | |
| dc.subject.mesh | Cesium Radioisotopes | |
| dc.subject.mesh | Dose-Response Relationship, Drug | |
| dc.subject.mesh | Dose-Response Relationship, Radiation | |
| dc.subject.mesh | Gamma Rays | |
| dc.subject.mesh | Intestine, Small | |
| dc.subject.mesh | Male | |
| dc.subject.mesh | Mice | |
| dc.subject.mesh | Time Factors | |
| dc.subject.mesh | Vincristine | |
| dc.title | Gross and cellular response of intestinal crypts to single and fractionated doses of vincristine plus radiation: the influence of time between modalities. | en |
| dc.type | Article | en |
| dc.contributor.department | Paterson Laboratories and Department of Radiotherapy, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, England | en |
| dc.identifier.journal | International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine | en |
| html.description.abstract | The response of intestinal crypts to single doses and four equal, daily fractions of vincristine (VCR) plus gamma-rays, has been measured by the crypt microcolony assay. Measurements were made for VCR given either 7 hours or 1 min before radiation. For the 7-hour interval, fractionating the VCR dose markedly increased the efficacy of the combination treatment. However at 1-min interval, no injury additional to that for gamma-rays alone could be demonstrated, with either one or four fractions. Histopathological studies showed that both VCR and gamma-rays alone caused cell death, but with different distributions in the crypt. For combined treatments, both VCR-and gamma-type damage could be recognized with the 7-hour interval, but at 1 min only gamma damage. It is suggested that mitotic delay induced by radiation may permit the repair of injury caused by simultaneously-delivered VCR. |