Gross and cellular response of intestinal crypts to single and fractionated doses of vincristine plus radiation: the influence of time between modalities.
AffiliationPaterson Laboratories and Department of Radiotherapy, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, England
MetadataShow full item record
AbstractThe response of intestinal crypts to single doses and four equal, daily fractions of vincristine (VCR) plus gamma-rays, has been measured by the crypt microcolony assay. Measurements were made for VCR given either 7 hours or 1 min before radiation. For the 7-hour interval, fractionating the VCR dose markedly increased the efficacy of the combination treatment. However at 1-min interval, no injury additional to that for gamma-rays alone could be demonstrated, with either one or four fractions. Histopathological studies showed that both VCR and gamma-rays alone caused cell death, but with different distributions in the crypt. For combined treatments, both VCR-and gamma-type damage could be recognized with the 7-hour interval, but at 1 min only gamma damage. It is suggested that mitotic delay induced by radiation may permit the repair of injury caused by simultaneously-delivered VCR.
CitationGross and cellular response of intestinal crypts to single and fractionated doses of vincristine plus radiation: the influence of time between modalities. 1982, 42 (3):305-16 Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.
JournalInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
- Topographic variations in the clonogenic response of intestinal crypts to cytotoxic treatments.
- Authors: Moore JV, Maunda KK
- Issue date: 1983 Mar
- Cell-survival characteristics of intestinal stem cells and crypts of gamm-irradiated mice.
- Authors: Yau HC, Cairnie AB
- Issue date: 1979 Oct
- The re-establishment of hypersensitive cells in the crypts of irradiated mouse intestine.
- Authors: Ijiri K, Potten CS
- Issue date: 1984 Nov
- Reproductive effects after exposure of male mice to vincristine and to a combination of X-rays and vincristine.
- Authors: Dobrzyńska MM, Czajka U, Słowikowska MG
- Issue date: 2005
- The in vivo interaction between vincristine and radiation in a C3H mammary carcinoma and the feet of CDF1 mice.
- Authors: Grau C, Høyer M, Overgaard J
- Issue date: 1994 Dec 1