Gross and cellular response of intestinal crypts to single and fractionated doses of vincristine plus radiation: the influence of time between modalities.
Affiliation
Paterson Laboratories and Department of Radiotherapy, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, EnglandIssue Date
1982-09
Metadata
Show full item recordAbstract
The response of intestinal crypts to single doses and four equal, daily fractions of vincristine (VCR) plus gamma-rays, has been measured by the crypt microcolony assay. Measurements were made for VCR given either 7 hours or 1 min before radiation. For the 7-hour interval, fractionating the VCR dose markedly increased the efficacy of the combination treatment. However at 1-min interval, no injury additional to that for gamma-rays alone could be demonstrated, with either one or four fractions. Histopathological studies showed that both VCR and gamma-rays alone caused cell death, but with different distributions in the crypt. For combined treatments, both VCR-and gamma-type damage could be recognized with the 7-hour interval, but at 1 min only gamma damage. It is suggested that mitotic delay induced by radiation may permit the repair of injury caused by simultaneously-delivered VCR.Citation
Gross and cellular response of intestinal crypts to single and fractionated doses of vincristine plus radiation: the influence of time between modalities. 1982, 42 (3):305-16 Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.Journal
International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and MedicineDOI
10.1080/09553008214551221PubMed ID
6982881Type
ArticleLanguage
enISSN
0020-7616ae974a485f413a2113503eed53cd6c53
10.1080/09553008214551221
Scopus Count
Collections
Related articles
- Topographic variations in the clonogenic response of intestinal crypts to cytotoxic treatments.
- Authors: Moore JV, Maunda KK
- Issue date: 1983 Mar
- Cell-survival characteristics of intestinal stem cells and crypts of gamm-irradiated mice.
- Authors: Yau HC, Cairnie AB
- Issue date: 1979 Oct
- The re-establishment of hypersensitive cells in the crypts of irradiated mouse intestine.
- Authors: Ijiri K, Potten CS
- Issue date: 1984 Nov
- Reproductive effects after exposure of male mice to vincristine and to a combination of X-rays and vincristine.
- Authors: Dobrzyńska MM, Czajka U, Słowikowska MG
- Issue date: 2005
- The in vivo interaction between vincristine and radiation in a C3H mammary carcinoma and the feet of CDF1 mice.
- Authors: Grau C, Høyer M, Overgaard J
- Issue date: 1994 Dec 1