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    The spatial organization of the hierarchical proliferative cells of the crypts of the small intestine into clusters of 'synchronized' cells.

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    Authors
    Potten, Christopher S
    Chwalinski, S
    Swindell, Ric
    Palmer, Michael K
    Affiliation
    Paterson Laboratories and Medical Statistics, Christie Hospital, Manchester
    Issue Date
    1982-07
    
    Metadata
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    Abstract
    A statistical analysis of the distribution of [3H]TdR-labelled cells in longitudinal and transverse sections of crypts from the ileum of the mouse, indicated that there was a strong tendency for labelled or unlabelled cells to be associated in short vertical runs and lateral clumps, suggesting the presence of clusters of labelled cells on the sides of the crypts. A model is discussed for the cellular spatial organization of the crypt that proposes a vertical alignment of the cells within branches of the proliferative cell lineage. The model would predict vertical alignment of partially synchronized cells as well as some lateral clumping. In the present studies mitoses were not observed at higher levels in the crypt than labelled (S phase) cells. This observation would be predicted by the non-random spatial organization suggested by the model. The model would also make certain predictions concerning cell migration. These are discussed in relation to cell migration studies which include evidence that migration continues in the absence of mitotic activity.
    Citation
    The spatial organization of the hierarchical proliferative cells of the crypts of the small intestine into clusters of 'synchronized' cells. 1982, 15 (4):351-70 Cell Tissue Kinet
    Journal
    Cell and Tissue Kinetics
    URI
    http://hdl.handle.net/10541/134094
    PubMed ID
    7105127
    Type
    Article
    Language
    en
    ISSN
    0008-8730
    Collections
    All Christie Publications

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