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dc.contributor.authorCharlesworth, Julie D
dc.contributor.authorChu, Yung-Hua
dc.contributor.authorO'Connor, Peter J
dc.contributor.authorCraig, Alister W
dc.date.accessioned2011-06-21T15:39:08Z
dc.date.available2011-06-21T15:39:08Z
dc.date.issued1981
dc.identifier.citationEffect of pretreatment by feeding acetylaminofluorene on methylated purines formed in rat liver DNA after administration of dimethylnitrosamine. 1981, 2 (4):329-42 Carcinogenesisen
dc.identifier.issn0143-3334
dc.identifier.pmid7273314
dc.identifier.doi10.1093/carcin/2.4.329
dc.identifier.urihttp://hdl.handle.net/10541/134089
dc.description.abstractMethylated purines were determined in the liver and kidney DNA of rats that had been pretreated for several weeks by inclusion of 2-acetylaminofluorene in the diet and then given single injections of N,N-dimethylnitrosamine. In comparison ith relevant controls the capacity to remove O(6)-methylguanine from the livers of the pretreated animals was enhanced but there was no evidence for a similar effect in kidney. No market effects of this pretreatment were observed for the removal of 3-methyladenine or 7-methylguanine. The data indicate that an inducing agent may affect the capacity of an animal to repair DNA which is subsequently damaged by another agent of chemically different identity. The mechanisms involved are not clear but potentially these observations have wide implications when organisms are exposed to a variety of chemicals.
dc.language.isoenen
dc.subject.mesh2-Acetylaminofluorene
dc.subject.meshAnimals
dc.subject.meshDNA
dc.subject.meshDNA-Directed DNA Polymerase
dc.subject.meshDiet
dc.subject.meshDimethylnitrosamine
dc.subject.meshGrowth
dc.subject.meshLiver
dc.subject.meshMale
dc.subject.meshPurines
dc.subject.meshRats
dc.subject.meshRats, Inbred Strains
dc.subject.meshThymidine
dc.titleEffect of pretreatment by feeding acetylaminofluorene on methylated purines formed in rat liver DNA after administration of dimethylnitrosamine.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, UKen
dc.identifier.journalCarcinogenesisen
html.description.abstractMethylated purines were determined in the liver and kidney DNA of rats that had been pretreated for several weeks by inclusion of 2-acetylaminofluorene in the diet and then given single injections of N,N-dimethylnitrosamine. In comparison ith relevant controls the capacity to remove O(6)-methylguanine from the livers of the pretreated animals was enhanced but there was no evidence for a similar effect in kidney. No market effects of this pretreatment were observed for the removal of 3-methyladenine or 7-methylguanine. The data indicate that an inducing agent may affect the capacity of an animal to repair DNA which is subsequently damaged by another agent of chemically different identity. The mechanisms involved are not clear but potentially these observations have wide implications when organisms are exposed to a variety of chemicals.


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