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    Effect of pretreatment by feeding acetylaminofluorene on methylated purines formed in rat liver DNA after administration of dimethylnitrosamine.

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    Authors
    Charlesworth, Julie D
    Chu, Yung-Hua
    O'Connor, Peter J
    Craig, Alister W
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, UK
    Issue Date
    1981
    
    Metadata
    Show full item record
    Abstract
    Methylated purines were determined in the liver and kidney DNA of rats that had been pretreated for several weeks by inclusion of 2-acetylaminofluorene in the diet and then given single injections of N,N-dimethylnitrosamine. In comparison ith relevant controls the capacity to remove O(6)-methylguanine from the livers of the pretreated animals was enhanced but there was no evidence for a similar effect in kidney. No market effects of this pretreatment were observed for the removal of 3-methyladenine or 7-methylguanine. The data indicate that an inducing agent may affect the capacity of an animal to repair DNA which is subsequently damaged by another agent of chemically different identity. The mechanisms involved are not clear but potentially these observations have wide implications when organisms are exposed to a variety of chemicals.
    Citation
    Effect of pretreatment by feeding acetylaminofluorene on methylated purines formed in rat liver DNA after administration of dimethylnitrosamine. 1981, 2 (4):329-42 Carcinogenesis
    Journal
    Carcinogenesis
    URI
    http://hdl.handle.net/10541/134089
    DOI
    10.1093/carcin/2.4.329
    PubMed ID
    7273314
    Type
    Article
    Language
    en
    ISSN
    0143-3334
    ae974a485f413a2113503eed53cd6c53
    10.1093/carcin/2.4.329
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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