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    Effect of pretreatment of rats with N-methyl-N-nitrosourea on the repair of O(6)-methylguanine in liver DNA.

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    Authors
    Margison, Geoffrey P
    Affiliation
    Carcinogenesis Department, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK
    Issue Date
    1981
    
    Metadata
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    Abstract
    The capacity of rat liver to repair O6-methylguanine was determined by measuring the amounts of this base present in DNA after administration of N-[14C]methyl-N-nitrosourea (MNU). Chronic pretreatment of animals with unlabelled MNU either once weekly for 5 weeks or daily on weekdays for 14 days had either no marked effect or inhibited (or overloaded) repair activity, respectively. Pretreatment of rats with single doses of MNU initially decreased O6-methylguanine repair but this effect was lost as the pretreatment interval increased and by 40 h, activity had returned to control values. Administration of methylmethanesulphonate for 14 days had no effect on the removal of O6-methylguanine produced in liver DNA by [14C]MNU. None of the pretreatment schedules inhibited the removal of 3-methyladenine from liver DNA. These effects are contrasted with those produced by pretreatment of rats with dimethylnitrosamine (DMN) or 1,2-dimethylhydrazine which enhanced the capacity of the liver to remove O6-methylguanine produced by single dose of [14C]DMN.
    Citation
    Effect of pretreatment of rats with N-methyl-N-nitrosourea on the repair of O(6)-methylguanine in liver DNA. 1981, 2 (5):431-4 Carcinogenesis
    Journal
    Carcinogenesis
    URI
    http://hdl.handle.net/10541/134079
    DOI
    10.1093/carcin/2.5.431
    PubMed ID
    7273323
    Type
    Article
    Language
    en
    ISSN
    0143-3334
    ae974a485f413a2113503eed53cd6c53
    10.1093/carcin/2.5.431
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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