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dc.contributor.authorGuiotto, A
dc.contributor.authorRodighiero, P
dc.contributor.authorPastorini, G
dc.contributor.authorBordin, F
dc.contributor.authorBaccichetti, F
dc.contributor.authorCarlassare, F
dc.contributor.authorVedaldi, D
dc.contributor.authorDall'Acqua, F
dc.contributor.authorLand, Edward J
dc.date.accessioned2011-06-21T16:32:31Z
dc.date.available2011-06-21T16:32:31Z
dc.date.issued1981-07
dc.identifier.citationA new water soluble derivative of 4,5'-dimethylangelicin as a potential agent for photochemotherapy. 1981, 36 (7):536-50 Farmaco Scien
dc.identifier.issn0430-0920
dc.identifier.pmid7274439
dc.identifier.urihttp://hdl.handle.net/10541/134075
dc.description.abstractA water soluble derivative of 4,5'-dimethylangelicin (I) having a long chain linking an amino group to the planar furocoumarinic moiety, that is 4'-N,N-dimethylaminoethoxymethyl-4,5'-dimethylangelicin (III), has been prepared. This compound is able to form effectively the intercalated complex with DNA like the previously prepared 4'-aminomethyl-4,5'-dimethylangelicin (II), however while the compound (II) showed very poor photobinding to DNA, the new derivative (III) shows high photobinding to the macromolecule. It is proposed that these data illustrate the importance of the geometry of intercalation for the subsequent covalent photobinding to the macromolecule. Also some photophysical data of (II) and of (III) appear to confirm the critical role of the position assumed by the chromophore of the two compounds when intercalated in duplex DNA. The compound (III) displays high photobiological effects, also in terms of antiproliferative activity as shown by its capacity to inhibit DNA and RNA synthesis in Ehrlich cells, the growth of an E. coli culture and the infectivity of T2 phage. (III) on the basis of these properties seems to deserve a clinical evaluation of its potential photochemotherapeutic activity in the treatment of psoriasis.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCarcinoma, Ehrlich Tumor
dc.subject.meshCell Division
dc.subject.meshChemical Phenomena
dc.subject.meshChemistry
dc.subject.meshDNA, Neoplasm
dc.subject.meshGuinea Pigs
dc.subject.meshMice
dc.subject.meshPhotochemotherapy
dc.subject.meshPsoralens
dc.subject.meshRNA, Neoplasm
dc.subject.meshSkin Diseases
dc.subject.meshSolubility
dc.titleA new water soluble derivative of 4,5'-dimethylangelicin as a potential agent for photochemotherapy.en
dc.typeArticleen
dc.identifier.journalIl Farmaco; Edizione Scientificaen
html.description.abstractA water soluble derivative of 4,5'-dimethylangelicin (I) having a long chain linking an amino group to the planar furocoumarinic moiety, that is 4'-N,N-dimethylaminoethoxymethyl-4,5'-dimethylangelicin (III), has been prepared. This compound is able to form effectively the intercalated complex with DNA like the previously prepared 4'-aminomethyl-4,5'-dimethylangelicin (II), however while the compound (II) showed very poor photobinding to DNA, the new derivative (III) shows high photobinding to the macromolecule. It is proposed that these data illustrate the importance of the geometry of intercalation for the subsequent covalent photobinding to the macromolecule. Also some photophysical data of (II) and of (III) appear to confirm the critical role of the position assumed by the chromophore of the two compounds when intercalated in duplex DNA. The compound (III) displays high photobiological effects, also in terms of antiproliferative activity as shown by its capacity to inhibit DNA and RNA synthesis in Ehrlich cells, the growth of an E. coli culture and the infectivity of T2 phage. (III) on the basis of these properties seems to deserve a clinical evaluation of its potential photochemotherapeutic activity in the treatment of psoriasis.


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