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    A new water soluble derivative of 4,5'-dimethylangelicin as a potential agent for photochemotherapy.

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    Authors
    Guiotto, A
    Rodighiero, P
    Pastorini, G
    Bordin, F
    Baccichetti, F
    Carlassare, F
    Vedaldi, D
    Dall'Acqua, F
    Land, Edward J
    Issue Date
    1981-07
    
    Metadata
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    Abstract
    A water soluble derivative of 4,5'-dimethylangelicin (I) having a long chain linking an amino group to the planar furocoumarinic moiety, that is 4'-N,N-dimethylaminoethoxymethyl-4,5'-dimethylangelicin (III), has been prepared. This compound is able to form effectively the intercalated complex with DNA like the previously prepared 4'-aminomethyl-4,5'-dimethylangelicin (II), however while the compound (II) showed very poor photobinding to DNA, the new derivative (III) shows high photobinding to the macromolecule. It is proposed that these data illustrate the importance of the geometry of intercalation for the subsequent covalent photobinding to the macromolecule. Also some photophysical data of (II) and of (III) appear to confirm the critical role of the position assumed by the chromophore of the two compounds when intercalated in duplex DNA. The compound (III) displays high photobiological effects, also in terms of antiproliferative activity as shown by its capacity to inhibit DNA and RNA synthesis in Ehrlich cells, the growth of an E. coli culture and the infectivity of T2 phage. (III) on the basis of these properties seems to deserve a clinical evaluation of its potential photochemotherapeutic activity in the treatment of psoriasis.
    Citation
    A new water soluble derivative of 4,5'-dimethylangelicin as a potential agent for photochemotherapy. 1981, 36 (7):536-50 Farmaco Sci
    Journal
    Il Farmaco; Edizione Scientifica
    URI
    http://hdl.handle.net/10541/134075
    PubMed ID
    7274439
    Type
    Article
    Language
    en
    ISSN
    0430-0920
    Collections
    All Paterson Institute for Cancer Research

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