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    Circadian rhythms in the epithelial cells and the pericryptal fibroblast sheath in three different sites in the murine intestinal tract.

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    Authors
    Neal, J Valerie
    Potten, Christopher S
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1981-11
    
    Metadata
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    Abstract
    Variations in percentage labelling (LI) and mitotic activity (mitoses per crypt) have been studied over a 24-hr period in the epithelial cells and pericryptal fibroblast sheath (PCFS) of the small intestine, caecum, and colon of the mouse. All three tissues displayed clear, synchronized circadian rhythms in DNA-synthetic activity in both the epithelial cells and PCFS. Peak values were coincident within a tissue, but staggered between tissues. In the epithelial cells, peak mitotic values were found between 3 and 6 hr after the peak LI values. The low level of mitotic activity in the PCFS appeared to be synchronized with the rhythms in the adjacent epithelia. The epithelial cells of the lowest crypt third displayed the clearest circadian rhythms. However, the PCFS cells at all levels produced similar curves. A craniocaudal wave of proliferative activity is proposed.
    Citation
    Circadian rhythms in the epithelial cells and the pericryptal fibroblast sheath in three different sites in the murine intestinal tract. 1981, 14 (6):581-7 Cell Tissue Kinet
    Journal
    Cell and Tissue Kinetics
    URI
    http://hdl.handle.net/10541/133916
    PubMed ID
    7296624
    Type
    Article
    Language
    en
    ISSN
    0008-8730
    Collections
    All Paterson Institute for Cancer Research

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