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    The relationship of G0 to the cell cycle of haemopoietic spleen colony-forming cells.

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    Authors
    Lord, Brian I
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Withington, Manchester
    Issue Date
    1981-07
    
    Metadata
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    Abstract
    Normal haemopoietic stem cells, defined here as spleen colony-forming units (CFUs), are slowly proliferating and are generally considered to spend most of their time in the non-proliferative G0-state. A series of experiments using various combinations of the stem cell proliferation inhibitor (NBME-IV) and stimulator (RBME-III) together with vinblastine as a mitotic blocking agent was designed to determine the location of the G0-state relative to the cell cycle of the CFUs. From a knowledge of the effects of these agents, the expected results from three different G0-cell cycle models were charted and compared with the observed proliferative behaviour of the CFUs following these treatments. It was concluded that the out-of-style G0-state is located at the end of the G1-phase of the cycle, so that on receiving a stimulatory signal, the CFUs can rapidly enter the DNA-synthesis phase.
    Citation
    The relationship of G0 to the cell cycle of haemopoietic spleen colony-forming cells. 1981, 14 (4):425-31 Cell Tissue Kinet
    Journal
    Cell and Tissue Kinetics
    URI
    http://hdl.handle.net/10541/133915
    DOI
    10.1111/j.1365-2184.1981.tb00549.x
    PubMed ID
    7261026
    Type
    Article
    Language
    en
    ISSN
    0008-8730
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2184.1981.tb00549.x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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