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dc.contributor.authorSchor, Seth L
dc.contributor.authorSchor, Ana M
dc.contributor.authorBazill, George W
dc.date.accessioned2011-06-19T21:43:37Z
dc.date.available2011-06-19T21:43:37Z
dc.date.issued1981-04
dc.identifier.citationThe effects of fibronectin on the migration of human foreskin fibroblasts and Syrian hamster melanoma cells into three-dimensional gels of native collagen fibres. 1981, 48:301-14 J. Cell. Sci.en
dc.identifier.issn0021-9533
dc.identifier.pmid7276092
dc.identifier.urihttp://hdl.handle.net/10541/133773
dc.description.abstractThe effects of fibronectin on the migration of human skin fibroblasts and Syrian hamster melanoma cells into 3-dimensional gels of native collagen fibres have been examined. Cell migration into the 3-dimensional gel was measured by plating cells on the gel surface and then determining the percentage of cells within the gel at various times thereafter by direct microscopic examination. We find that fibronectin bound to collagen inhibits the migration of human skin fibroblasts and stimulates the migration of melanoma cells into the gel matrix. Fibronectin had no apparent effect on cell adhesion to the collagen gels, proliferation or morphology under the conditions studied.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Count
dc.subject.meshCell Division
dc.subject.meshCell Movement
dc.subject.meshCells, Cultured
dc.subject.meshCollagen
dc.subject.meshCricetinae
dc.subject.meshFibroblasts
dc.subject.meshFibronectins
dc.subject.meshHumans
dc.subject.meshMelanoma
dc.subject.meshMesocricetus
dc.subject.meshNeoplasms, Experimental
dc.subject.meshSkin
dc.titleThe effects of fibronectin on the migration of human foreskin fibroblasts and Syrian hamster melanoma cells into three-dimensional gels of native collagen fibres.en
dc.typeArticleen
dc.identifier.journalJournal of Cell Scienceen
html.description.abstractThe effects of fibronectin on the migration of human skin fibroblasts and Syrian hamster melanoma cells into 3-dimensional gels of native collagen fibres have been examined. Cell migration into the 3-dimensional gel was measured by plating cells on the gel surface and then determining the percentage of cells within the gel at various times thereafter by direct microscopic examination. We find that fibronectin bound to collagen inhibits the migration of human skin fibroblasts and stimulates the migration of melanoma cells into the gel matrix. Fibronectin had no apparent effect on cell adhesion to the collagen gels, proliferation or morphology under the conditions studied.


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