The effects of fibronectin on the migration of human foreskin fibroblasts and Syrian hamster melanoma cells into three-dimensional gels of native collagen fibres.
Abstract
The effects of fibronectin on the migration of human skin fibroblasts and Syrian hamster melanoma cells into 3-dimensional gels of native collagen fibres have been examined. Cell migration into the 3-dimensional gel was measured by plating cells on the gel surface and then determining the percentage of cells within the gel at various times thereafter by direct microscopic examination. We find that fibronectin bound to collagen inhibits the migration of human skin fibroblasts and stimulates the migration of melanoma cells into the gel matrix. Fibronectin had no apparent effect on cell adhesion to the collagen gels, proliferation or morphology under the conditions studied.Citation
The effects of fibronectin on the migration of human foreskin fibroblasts and Syrian hamster melanoma cells into three-dimensional gels of native collagen fibres. 1981, 48:301-14 J. Cell. Sci.Journal
Journal of Cell SciencePubMed ID
7276092Type
ArticleLanguage
enISSN
0021-9533Collections
Related articles
- Cell proliferation and migration on collagen substrata in vitro.
- Authors: Schor SL
- Issue date: 1980 Feb
- Cell migration through three-dimensional gels of native collagen fibres: collagenolytic activity is not required for the migration of two permanent cell lines.
- Authors: Schor SL, Allen TD, Harrison CJ
- Issue date: 1980 Dec
- The effects of fibronectin on the adhesion and migration of chinese hamster ovary cells on collagen substrata.
- Authors: Schor SL, Schor AM, Bazill GW
- Issue date: 1981 Jun
- Substratum-dependent stimulation of fibroblast migration by the gelatin-binding domain of fibronectin.
- Authors: Schor SL, Ellis I, Dolman C, Banyard J, Humphries MJ, Mosher DF, Grey AM, Mould AP, Sottile J, Schor AM
- Issue date: 1996 Oct
- Promotion by fibronectin of collagen gel contraction mediated by human corneal fibroblasts.
- Authors: Liu Y, Yanai R, Lu Y, Kimura K, Nishida T
- Issue date: 2006 Nov