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    Evaluation of radiation-induced chromosomal aberrations in human peripheral blood lymphocytes in vitro: result of an IAEA-coordinated programme.

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    Authors
    Bianchi, M
    Bianchi, N O
    Brewen, J G
    Buckton, K E
    Fabry, L
    Fischer, P
    Gooch, P C
    Kucerova, M
    Léonard, A
    Mukherjee, R N
    Mukherjee, U
    Nakai, S
    Natarajan, A T
    Obe, G
    Palitti, F
    Pohl-Rüling, J
    Schwarzacher, H G
    Scott, David
    Sharma, T
    Takahashi, E
    Tanzarella, C
    Van Buul, P P
    Issue Date
    1982-10
    
    Metadata
    Show full item record
    Abstract
    The results of an IAEA coordinated programme on radiation induced chromosomal aberrations in human peripheral blood lymphocytes in vitro are presented. In a master experiment, a whole blood sample from one donor was irradiated with 200 R of X-rays. Different fixation times from 46 to 82 h were used. The progression of cells into mitosis was monitored by BrdUrd incorporation. 14 investigators took part in the scoring of chromosomal aberrations. The main conclusions of this study are: (1) The mean frequencies of aberrations changed with fixation time. (2) The number of cells scored as aberrant by different laboratories was very similar, but there was variability in the number of aberrations scored per aberrant cell. (3) The differences in the frequencies of aberrations between laboratories were minimal when the scoring was restricted to the first major peak of mitotic activity and sufficient cells were scored. It is concluded that using controlled experimentals conditions, human peripheral blood lymphocytes can effectively be used as a reliable biological dosimeter for absorbed radiation dose.
    Citation
    Evaluation of radiation-induced chromosomal aberrations in human peripheral blood lymphocytes in vitro: result of an IAEA-coordinated programme. 1982, 96 (2-3):233-42 Mutat. Res.
    Journal
    Mutation Research
    URI
    http://hdl.handle.net/10541/133541
    PubMed ID
    7144799
    Type
    Article
    Language
    en
    ISSN
    0027-5107
    Collections
    All Paterson Institute for Cancer Research

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