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dc.contributor.authorShalet, Stephen M
dc.contributor.authorWhitehead, E
dc.contributor.authorChapman, A J
dc.contributor.authorBeardwell, Colin G
dc.date.accessioned2011-06-16T21:23:40Z
dc.date.available2011-06-16T21:23:40Z
dc.date.issued1981-01
dc.identifier.citationThe effects of growth hormone therapy in children with radiation-induced growth hormone deficiency. 1981, 70 (1):81-6 Acta Paediatr Scanden
dc.identifier.issn0001-656X
dc.identifier.pmid7211380
dc.identifier.urihttp://hdl.handle.net/10541/133536
dc.description.abstractThe effects of growth hormone (GH) therapy were studied in 6 children, previously treated for brain tumours which did not directly involve the hypothalamic-pituitary axis, and who had received cranial irradiation between 2.1 and 10 years earlier. All 6 were short with a standing height standard deviation score (SDS) from -1.7 to -3.3. Impaired growth hormone responses to an insulin tolerance test (ITT) were observed in all 6 and to a Bovril stimulation test in 5 children. The remainder of pituitary function was essentially normal. All 6 were prepubertal and 5 had a retarded bone age. During the pre-treatment year the 6 children's growth rates varied fom 2.0 to 5.1 cm. Subsequently all received human GH in a dose of 5 units 3 times weekly for 1 year. The growth rate in each was at least 2 cm greater during the treatment year than the pre-treatment year. Growth during the treatment year ranged from 6.0 to 10.1 cm. In 5 of the 6 the improvement in growth rate could be totally ascribed to the GH therapy. In the sixth there was significant pubertal maturation during the treatment year and only in this subject did the bone age advance at a significantly greater rate than the chronological age.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshBody Height
dc.subject.meshBrain Neoplasms
dc.subject.meshChild
dc.subject.meshFemale
dc.subject.meshGrowth
dc.subject.meshGrowth Disorders
dc.subject.meshGrowth Hormone
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPituitary Gland
dc.subject.meshRadiotherapy
dc.titleThe effects of growth hormone therapy in children with radiation-induced growth hormone deficiency.en
dc.typeArticleen
dc.identifier.journalActa Paediatrica Scandinavicaen
html.description.abstractThe effects of growth hormone (GH) therapy were studied in 6 children, previously treated for brain tumours which did not directly involve the hypothalamic-pituitary axis, and who had received cranial irradiation between 2.1 and 10 years earlier. All 6 were short with a standing height standard deviation score (SDS) from -1.7 to -3.3. Impaired growth hormone responses to an insulin tolerance test (ITT) were observed in all 6 and to a Bovril stimulation test in 5 children. The remainder of pituitary function was essentially normal. All 6 were prepubertal and 5 had a retarded bone age. During the pre-treatment year the 6 children's growth rates varied fom 2.0 to 5.1 cm. Subsequently all received human GH in a dose of 5 units 3 times weekly for 1 year. The growth rate in each was at least 2 cm greater during the treatment year than the pre-treatment year. Growth during the treatment year ranged from 6.0 to 10.1 cm. In 5 of the 6 the improvement in growth rate could be totally ascribed to the GH therapy. In the sixth there was significant pubertal maturation during the treatment year and only in this subject did the bone age advance at a significantly greater rate than the chronological age.


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