• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Production of monocyte/macrophage colony-stimulating factor by preadipocyte cell lines derived from murine marrow stroma.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Lanotte, Michael
    Metcalf, D
    Dexter, T Michael
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Withington, Manchester M20 9BX, England
    Issue Date
    1982-07
    
    Metadata
    Show full item record
    Abstract
    Three preadipocyte cell lines that have been independently derived from bone marrow stroma (Lanotte et al, 1982) have been tested for their capacity to produce granulocyte, macrophage, and erythroid colony-stimulating factors (CSFs). All elaborated colony-stimulating material that was active upon adult mouse marrow granulocyte/macrophage colony-forming cells (M-CFC) but not foetal liver GM-CFC. The major activity was characterised as a monocyte-macrophage colony-stimulating factor (M-CSF), and the pattern of colony stimulation was similar to that seen after addition of highly purified L-cell CSF. Furthermore, the stimulating activity was specifically neutralised by rabbit anti-L cell CSF antibodies. No evidence was found for stimulation of multipotential or erythroid colony-forming cells, only few granulocytic colonies were detected, and the stimulating activity had no mouse strain restriction. All cell lines produced large quantities of M-CSF; however, the production was found to be modulated during the adipogenesis process. A peak in M-CSF production corresponded to the period of growth arrest after confluence of the stromal cells was reached and when adipocyte maturation was at an early stage. A marked depression in M-CSF secretion was associated with the final steps of adipocyte maturation.
    Citation
    Production of monocyte/macrophage colony-stimulating factor by preadipocyte cell lines derived from murine marrow stroma. 1982, 112 (1):123-7 J. Cell. Physiol.
    Journal
    Journal of Cellular Physiology
    URI
    http://hdl.handle.net/10541/133516
    DOI
    10.1002/jcp.1041120118
    PubMed ID
    6980887
    Type
    Article
    Language
    en
    ISSN
    0021-9541
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcp.1041120118
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Monocyte-conditioned medium and interleukin 1 induce granulocyte-macrophage colony-stimulating factor production in the adherent cell layer of murine bone marrow cultures.
    • Authors: Løvhaug D, Pelus LM, Nordlie EM, Bøyum A, Moore MA
    • Issue date: 1986 Dec
    • Effect of lipopolysaccharide on the production of colony-stimulating factors by the stromal cells in long-term bone marrow culture.
    • Authors: Wang SY, Su CY, Hsu ML, Chen LY, Tzeng CH, Ho CK
    • Issue date: 1991 Feb
    • Homing efficiency and hematopoietic reconstitution of bone marrow-derived stroma cells expanded by recombinant human macrophage-colony stimulating factor in vitro.
    • Authors: Jin-Xiang F, Xiaofeng S, Jun-Chuan Q, Yan G, Xue-Guang Z
    • Issue date: 2004 Dec
    • Clonal analysis of progenitor cell commitment of granulocyte or macrophage production.
    • Authors: Metcalf D, Burgess AW
    • Issue date: 1982 Jun
    • Constitutive production of colony-stimulating factors by human hepatoma cell lines: possible correlation with cell differentiation.
    • Authors: Wang SY, Chen LY, Tsai TF, Su TS, Choo KB, Ho CK
    • Issue date: 1996 Feb
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.