Haemoglobin and prognosis in childhood acute lymphoblastic leukaemia.
| dc.contributor.author | Hann, I M | |
| dc.contributor.author | Scarffe, J Howard | |
| dc.contributor.author | Palmer, Michael K | |
| dc.contributor.author | Evans, D I | |
| dc.contributor.author | Jones, P H | |
| dc.date.accessioned | 2011-06-16T21:13:09Z | |
| dc.date.available | 2011-06-16T21:13:09Z | |
| dc.date.issued | 1981-09 | |
| dc.identifier.citation | Haemoglobin and prognosis in childhood acute lymphoblastic leukaemia. 1981, 56 (9):684-6 Arch. Dis. Child. | en |
| dc.identifier.issn | 1468-2044 | |
| dc.identifier.pmid | 6945824 | |
| dc.identifier.doi | 10.1136/adc.56.9.684 | |
| dc.identifier.uri | http://hdl.handle.net/10541/133514 | |
| dc.description.abstract | Two hundred and nine children presenting consecutively with acute lymphoblastic leukaemia to a regional paediatric oncology unit were investigated to determine the prognostic significance of various factors at diagnosis. There was a strong positive correlation between the pretreatment haemoglobin level and the percentage of bone marrow blast cells in S phase of the cell cycle as assessed by flow cytometry. Patients with T- and B-cell leukaemia had significantly higher haemoglobin levels than non-B non-T patients. In patients with total white cell counts less than 20 X 10(9)/l, aged less than 13 years, and no mediastinal mass, there was no association of haemoglobin with length of first remission. However, among those with white blood counts greater than 20 +/- 10(9)/l there was a strong positive trend towards shorter remission with higher haemoglobin levels. Children with high white blood counts at diagnosis and low haemoglobin levels may have a better prognosis than predicted by the white blood count alone. | |
| dc.language.iso | en | en |
| dc.subject.mesh | Child | |
| dc.subject.mesh | Hemoglobins | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Leukemia, Lymphoid | |
| dc.subject.mesh | Prognosis | |
| dc.subject.mesh | Time Factors | |
| dc.title | Haemoglobin and prognosis in childhood acute lymphoblastic leukaemia. | en |
| dc.type | Article | en |
| dc.contributor.department | Department of Haematology and Department of Oncology, Royal Manchester Children's Hospital | en |
| dc.identifier.journal | Archives of Disease in Childhood | en |
| html.description.abstract | Two hundred and nine children presenting consecutively with acute lymphoblastic leukaemia to a regional paediatric oncology unit were investigated to determine the prognostic significance of various factors at diagnosis. There was a strong positive correlation between the pretreatment haemoglobin level and the percentage of bone marrow blast cells in S phase of the cell cycle as assessed by flow cytometry. Patients with T- and B-cell leukaemia had significantly higher haemoglobin levels than non-B non-T patients. In patients with total white cell counts less than 20 X 10(9)/l, aged less than 13 years, and no mediastinal mass, there was no association of haemoglobin with length of first remission. However, among those with white blood counts greater than 20 +/- 10(9)/l there was a strong positive trend towards shorter remission with higher haemoglobin levels. Children with high white blood counts at diagnosis and low haemoglobin levels may have a better prognosis than predicted by the white blood count alone. |