Haemoglobin and prognosis in childhood acute lymphoblastic leukaemia.
Affiliation
Department of Haematology and Department of Oncology, Royal Manchester Children's HospitalIssue Date
1981-09
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Two hundred and nine children presenting consecutively with acute lymphoblastic leukaemia to a regional paediatric oncology unit were investigated to determine the prognostic significance of various factors at diagnosis. There was a strong positive correlation between the pretreatment haemoglobin level and the percentage of bone marrow blast cells in S phase of the cell cycle as assessed by flow cytometry. Patients with T- and B-cell leukaemia had significantly higher haemoglobin levels than non-B non-T patients. In patients with total white cell counts less than 20 X 10(9)/l, aged less than 13 years, and no mediastinal mass, there was no association of haemoglobin with length of first remission. However, among those with white blood counts greater than 20 +/- 10(9)/l there was a strong positive trend towards shorter remission with higher haemoglobin levels. Children with high white blood counts at diagnosis and low haemoglobin levels may have a better prognosis than predicted by the white blood count alone.Citation
Haemoglobin and prognosis in childhood acute lymphoblastic leukaemia. 1981, 56 (9):684-6 Arch. Dis. Child.Journal
Archives of Disease in ChildhoodDOI
10.1136/adc.56.9.684PubMed ID
6945824Type
ArticleLanguage
enISSN
1468-2044ae974a485f413a2113503eed53cd6c53
10.1136/adc.56.9.684
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