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dc.contributor.authorJohnson, P J
dc.contributor.authorMelia, W M
dc.contributor.authorPalmer, Michael K
dc.contributor.authorPortmann, B
dc.contributor.authorWilliams, R
dc.date.accessioned2011-06-16T20:48:51Z
dc.date.available2011-06-16T20:48:51Z
dc.date.issued1981-10
dc.identifier.citationRelationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma. 1981, 44 (4):502-5 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid6170301
dc.identifier.urihttp://hdl.handle.net/10541/133512
dc.description.abstractAn analysis of survival time of 57 West European patients with hepatocellular carcinoma was carried out to define which of several possible factors (age, sex, cirrhosis and raised serum alpha-foetoprotein (AFP)) influenced survival. Although survival was significantly longer in younger patients (P less than 0.02) and in patients with normal serum AFP (P less than 0.01), multivariate analysis showed that significant variation in survival time is better explained by the single factor, the presence of cirrhosis, than by AFP level. This does not seem to apply for patients with this tumour in Africa and the Far East, and there may be a fundamental difference in the natural history of the tumour between high- and low-incidence areas.
dc.language.isoenen
dc.subjectLiver Canceren
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAge Factors
dc.subject.meshAged
dc.subject.meshCarcinoma, Hepatocellular
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLiver Cirrhosis
dc.subject.meshLiver Neoplasms
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPrognosis
dc.subject.meshalpha-Fetoproteins
dc.titleRelationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma.en
dc.typeArticleen
dc.contributor.departmentLiver Unit, Kin's College Hospital and Medical School, Denmark Hill, London SE5en
dc.identifier.journalBritish Journal of Canceren
html.description.abstractAn analysis of survival time of 57 West European patients with hepatocellular carcinoma was carried out to define which of several possible factors (age, sex, cirrhosis and raised serum alpha-foetoprotein (AFP)) influenced survival. Although survival was significantly longer in younger patients (P less than 0.02) and in patients with normal serum AFP (P less than 0.01), multivariate analysis showed that significant variation in survival time is better explained by the single factor, the presence of cirrhosis, than by AFP level. This does not seem to apply for patients with this tumour in Africa and the Far East, and there may be a fundamental difference in the natural history of the tumour between high- and low-incidence areas.


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