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dc.contributor.authorKeegan, A
dc.contributor.authorHill, C
dc.contributor.authorKumar, Shant
dc.contributor.authorPhillips, P
dc.contributor.authorSchor, Ana M
dc.contributor.authorWeiss, J
dc.date.accessioned2011-06-16T20:32:09Z
dc.date.available2011-06-16T20:32:09Z
dc.date.issued1982-06
dc.identifier.citationPurified tumour angiogenesis factor enhances proliferation of capillary, but not aortic, endothelial cells in vitro. 1982, 55:261-76 J. Cell. Sci.en
dc.identifier.issn0021-9533
dc.identifier.pmid7107726
dc.identifier.urihttp://hdl.handle.net/10541/133511
dc.description.abstractPurified tumour angiogenesis factor (TAF) obtained from rat Walker 256 carcinoma and found to induce neovascularization in vivo was examined for its effect on endothelial cell cultures of capillary (CBEC), cow aorta (CAEC) and pig aorta (PAEC) in vitro. Treatment with TAF increased the growth of capillary but not aortic endothelial cells, and then only when the cells were growing on a native collagen substratum. These data show an important growth difference between endothelial cells, in that the ability to proliferate in response to TAF depends not only on the substratum used but also on the vascular origin of the cells.
dc.language.isoenen
dc.subject.meshAngiogenesis Inducing Agents
dc.subject.meshAnimals
dc.subject.meshAorta
dc.subject.meshCapillaries
dc.subject.meshCarcinoma 256, Walker
dc.subject.meshCattle
dc.subject.meshCell Division
dc.subject.meshCells, Cultured
dc.subject.meshEndothelium
dc.subject.meshFibroblasts
dc.subject.meshGrowth Substances
dc.subject.meshRats
dc.subject.meshSwine
dc.titlePurified tumour angiogenesis factor enhances proliferation of capillary, but not aortic, endothelial cells in vitro.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital, Manchester, M13 9PL, UKen
dc.identifier.journalJournal of Cell Scienceen
html.description.abstractPurified tumour angiogenesis factor (TAF) obtained from rat Walker 256 carcinoma and found to induce neovascularization in vivo was examined for its effect on endothelial cell cultures of capillary (CBEC), cow aorta (CAEC) and pig aorta (PAEC) in vitro. Treatment with TAF increased the growth of capillary but not aortic endothelial cells, and then only when the cells were growing on a native collagen substratum. These data show an important growth difference between endothelial cells, in that the ability to proliferate in response to TAF depends not only on the substratum used but also on the vascular origin of the cells.


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