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    Chemotherapy of metastatic carcinoma of the breast.

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    Authors
    Hancock, B
    Todd, Ian D
    Wilkinson, Peter M
    Affiliation
    Departments of Radiotherapy and Clinical Pharmacology, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK
    Issue Date
    1980-07
    
    Metadata
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    Abstract
    Thirty-four patients with metastatic breast carcinoma were treated with the following combination: methotrexate 60 mg/m2 i.v. days 1 and 8,5-fluorouracil 500 mg/m2 i.v. days 1 and 8, cyclophosphamide 100 mg/m2 daily for 14 days, and prednisolone 25 mg b.d. by mouth daily for 14 days. In 21/34 (62%) patients regression of tumour was maintained for at least three months and in six (18%) this was complete. The median duration of response was 15 months (range 6--33) and there was a significant difference in survival between responders and non-responders (P<0.01). Toxicity was acceptable although dose reduction was necessary in eight patients and in three patients treatment had to be discontinued.
    Citation
    Chemotherapy of metastatic carcinoma of the breast. 1980, 31 (4):433-6 Clin Radiol
    Journal
    Clinical Radiology
    URI
    http://hdl.handle.net/10541/133130
    DOI
    10.1016/S0009-9260(80)80184-X
    PubMed ID
    7418343
    Type
    Article
    Language
    en
    ISSN
    0009-9260
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0009-9260(80)80184-X
    Scopus Count
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