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dc.contributor.authorShalet, Stephen M
dc.date.accessioned2011-05-31T14:17:45Z
dc.date.available2011-05-31T14:17:45Z
dc.date.issued1982
dc.identifier.citationGrowth and hormonal status of children treated for brain tumours. 1982, 9 (3-4):284-93 Childs Brainen
dc.identifier.issn0302-2803
dc.identifier.pmid6809431
dc.identifier.urihttp://hdl.handle.net/10541/132397
dc.description.abstractThe adult survivors of the treatment of brain tumours in childhood are often short. Several adverse factors contribute to the impaired growth of these children including growth hormone (GH) deficiency, impaired spinal growth following spinal irradiation, chemotherapy, poor nutritional intake and recurrent tumour. The GH deficiency is due to radiation-induced damage to the hypothalamic-pituitary axis. GH is always the first pituitary hormone to be affected by such radiation damage but panhypopituitarism may occur if the radiation dose is sufficiently great. Preliminary results suggest that GH therapy will improve the growth rate of children with radiation-induced GH deficiency. Additional endocrine complications, which may occur following spinal irradiation, include thyroid dysfunction and ovarian failure due to direct radiation damage to the thyroid and the ovary.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshBody Height
dc.subject.meshBrain Neoplasms
dc.subject.meshChild
dc.subject.meshGrowth Disorders
dc.subject.meshGrowth Hormone
dc.subject.meshHumans
dc.subject.meshHypopituitarism
dc.subject.meshRadiation Dosage
dc.subject.meshRadiotherapy
dc.subject.meshThyrotropin
dc.subject.meshThyrotropin-Releasing Hormone
dc.titleGrowth and hormonal status of children treated for brain tumours.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology.CHristie Hospital, Manchester, Englanden
dc.identifier.journalChild's Brainen
html.description.abstractThe adult survivors of the treatment of brain tumours in childhood are often short. Several adverse factors contribute to the impaired growth of these children including growth hormone (GH) deficiency, impaired spinal growth following spinal irradiation, chemotherapy, poor nutritional intake and recurrent tumour. The GH deficiency is due to radiation-induced damage to the hypothalamic-pituitary axis. GH is always the first pituitary hormone to be affected by such radiation damage but panhypopituitarism may occur if the radiation dose is sufficiently great. Preliminary results suggest that GH therapy will improve the growth rate of children with radiation-induced GH deficiency. Additional endocrine complications, which may occur following spinal irradiation, include thyroid dysfunction and ovarian failure due to direct radiation damage to the thyroid and the ovary.


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