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    Studies of lectin binding to normal and neoplastic lymph nodes. II. Non-Hodgkin's lymphoma.

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    Authors
    Bramwell, Vivien H C
    Crowther, Derek
    Gallagher, John T
    Stoddart, R W
    Affiliation
    CRC Department of Medical Oncology, University of Manchester and Christie Hospital and Holt Radium Institute, Wilmslow Road, Manchester M20 9BX
    Issue Date
    1982-10
    
    Metadata
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    Abstract
    Fluorescein conjugated lectins have been used as histochemical stains in lymph node sections from 22 patients with non-Hodgkin's Lymphoma. Variations in the distribution and structure of glycoprotein sequences between the different types of lymphoma, and also normal nodes, have been detected. The lectin-binding patterns of neoplastic lymphocytes of small cell lymphomas, both follicular and diffuse, suggested a predominance of sialylated glycopeptides, as in normal small lymphocytes of the mantle zone of germinal centres. In contrast, the staining patterns of large cell follicular and diffuse lymphomas showed a greater diversity of carbohydrate structure, with enhanced cytoplasmic staining and increased numbers of incomplete oligosaccharide sequences. Heterogeneity of staining, together with reduced sialic acid expression at all cellular sites was a common feature of lymphoblastic lymphomas and seemed to be linked with a poor prognosis. The extracellular matrix of small cell follicular lymphomas showed altered saccharide content, but retained some degree of organization. The large cell follicular lymphomas were characterized by a prominent disorderly matrix, with staining characteristics which suggested shedding of surface membrane from component cells. The loss or disordered production of the normal extracellular matrix may reflect a breakdown of control mechanisms within neoplastic follicles.
    Citation
    Studies of lectin binding to normal and neoplastic lymph nodes. II. Non-Hodgkin's lymphoma. 1982, 46 (4):582-92 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/131910
    PubMed ID
    6182897
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Christie Publications

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