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dc.contributor.authorGallagher, P
dc.contributor.authorVose, Brent M
dc.contributor.authorMoore, Michael
dc.contributor.authorSchofield, Philip F
dc.date.accessioned2011-05-13T14:59:59Z
dc.date.available2011-05-13T14:59:59Z
dc.date.issued1982-01
dc.identifier.citationRole of autologous lymphocyte cytotoxicity in colonic neoplasia. 1982, 23 (1):31-5 Guten
dc.identifier.issn0017-5749
dc.identifier.pmid6976915
dc.identifier.doi10.1136/gut.23.1.31
dc.identifier.urihttp://hdl.handle.net/10541/129508
dc.description.abstractThe T-lymphocyte mediated killing of autologous carcinoma colon cells was investigated. There was no change in the incidence of activity with advanced disease, age, or nutritional status of the patient and no difference could be demonstrated in lymphocytes extracted from blood, draining lymph nodes, or the tumour itself. Nevertheless. T-lymphocyte activity did appear to be specific for the patients's own tumour, as it was rarely observed with allogeneic tumours. There was also no correlation with lymphocyte natural killer activity. The in vitro studies demonstrated patient specific T-lymphocyte activity in 23 of 47 patients with carcinoma of the colon, but the results do not correlate with clinical and pathological findings.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCell Line
dc.subject.meshColonic Neoplasms
dc.subject.meshCytotoxicity, Immunologic
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLymph Nodes
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshT-Lymphocytes
dc.titleRole of autologous lymphocyte cytotoxicity in colonic neoplasia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester.en
dc.identifier.journalGuten
html.description.abstractThe T-lymphocyte mediated killing of autologous carcinoma colon cells was investigated. There was no change in the incidence of activity with advanced disease, age, or nutritional status of the patient and no difference could be demonstrated in lymphocytes extracted from blood, draining lymph nodes, or the tumour itself. Nevertheless. T-lymphocyte activity did appear to be specific for the patients's own tumour, as it was rarely observed with allogeneic tumours. There was also no correlation with lymphocyte natural killer activity. The in vitro studies demonstrated patient specific T-lymphocyte activity in 23 of 47 patients with carcinoma of the colon, but the results do not correlate with clinical and pathological findings.


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