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    Role of autologous lymphocyte cytotoxicity in colonic neoplasia.

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    Authors
    Gallagher, P
    Vose, Brent M
    Moore, Michael
    Schofield, Philip F
    Affiliation
    Department of Immunology, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester.
    Issue Date
    1982-01
    
    Metadata
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    Abstract
    The T-lymphocyte mediated killing of autologous carcinoma colon cells was investigated. There was no change in the incidence of activity with advanced disease, age, or nutritional status of the patient and no difference could be demonstrated in lymphocytes extracted from blood, draining lymph nodes, or the tumour itself. Nevertheless. T-lymphocyte activity did appear to be specific for the patients's own tumour, as it was rarely observed with allogeneic tumours. There was also no correlation with lymphocyte natural killer activity. The in vitro studies demonstrated patient specific T-lymphocyte activity in 23 of 47 patients with carcinoma of the colon, but the results do not correlate with clinical and pathological findings.
    Citation
    Role of autologous lymphocyte cytotoxicity in colonic neoplasia. 1982, 23 (1):31-5 Gut
    Journal
    Gut
    URI
    http://hdl.handle.net/10541/129508
    DOI
    10.1136/gut.23.1.31
    PubMed ID
    6976915
    Type
    Article
    Language
    en
    ISSN
    0017-5749
    ae974a485f413a2113503eed53cd6c53
    10.1136/gut.23.1.31
    Scopus Count
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    All Paterson Institute for Cancer Research

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