Affiliation
Department of Immunology, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester.Issue Date
1982-01
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Show full item recordAbstract
The T-lymphocyte mediated killing of autologous carcinoma colon cells was investigated. There was no change in the incidence of activity with advanced disease, age, or nutritional status of the patient and no difference could be demonstrated in lymphocytes extracted from blood, draining lymph nodes, or the tumour itself. Nevertheless. T-lymphocyte activity did appear to be specific for the patients's own tumour, as it was rarely observed with allogeneic tumours. There was also no correlation with lymphocyte natural killer activity. The in vitro studies demonstrated patient specific T-lymphocyte activity in 23 of 47 patients with carcinoma of the colon, but the results do not correlate with clinical and pathological findings.Citation
Role of autologous lymphocyte cytotoxicity in colonic neoplasia. 1982, 23 (1):31-5 GutJournal
GutDOI
10.1136/gut.23.1.31PubMed ID
6976915Type
ArticleLanguage
enISSN
0017-5749ae974a485f413a2113503eed53cd6c53
10.1136/gut.23.1.31
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